XCL1 Antikörper (AA 21-114) (Biotin)

Produktnummer ABIN1390375

Produktdetails anti-XCL1 Antikörper (Biotin)

Target: XCL1 (Chemokine (C Motif) Ligand 1 (XCL1))

Bindungsspezifität: AA 21-114

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser XCL1 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Lymphotactin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu XCL1

Target: XCL1 (Chemokine (C Motif) Ligand 1 (XCL1))

Andere Bezeichnung: Lymphotactin/Xcl1 (XCL1 Produkte)

Hintergrund:

Synonyms: Lptn, LTN, XCL1 C mot chemokine 1, SCM 1 alpha, ATAC, Chemokine C Mot Ligand 1, Cytokine SCM-1, LPTN, LTN, Lymphotactin, Lymphotaxin, SCM-1-alpha, SCM1, SCYC1, Small inducible cytokine C1, Small Inducible Cytokine Subfamily C Member 1, Small-inducible cytokine C1, XC chemokine ligand 1, Xcl1, XCL1_HUMAN.

Background: Lymphotactin is a chemokine-like molecule produced selectively, if not exclusively, by activated CD8+ T cells (1). Lymphotactin is a C-type member of the chemokine superfamily, but retains only the 2nd and 4th of the four cysteine residues conserved in other chemokines (3,4). In normal tissues, lymphotactin is expressed at high levels in spleen, thymus, small intestine, and peripheral blood leukocytes, as well as at low levels in lung, prostate, and ovary (2). Lymphotactin is chemotactic for CD4+ and CD8+ T cells but not for monocytes, and induces a rise in intracellular calcium in peripheral blood lymphocytes (1). The specific receptor for lymphotactin is XCR1, a member of the G protein-coupled receptor family (5). The gene which encodes lymphotactin maps to human chromosome 1q23 (1,2).

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation