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Prostacyclin Receptor Antikörper (AA 101-200) (AbBy Fluor® 350)

PTGIR Reaktivität: Human IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 350
Produktnummer ABIN1390491
  • Target Alle Prostacyclin Receptor (PTGIR) Antikörper anzeigen
    Prostacyclin Receptor (PTGIR)
    Bindungsspezifität
    • 14
    • 7
    • 7
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 101-200
    Reaktivität
    • 47
    • 12
    • 4
    • 2
    • 2
    Human
    Wirt
    • 47
    • 3
    Kaninchen
    Klonalität
    • 47
    • 3
    Polyklonal
    Konjugat
    • 20
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Prostacyclin Receptor Antikörper ist konjugiert mit AbBy Fluor® 350
    Applikation
    • 27
    • 21
    • 18
    • 12
    • 12
    • 7
    • 4
    • 3
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human
    Homologie
    Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Prostaglandin I2 Receptor
    Isotyp
    IgG
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  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    Prostacyclin Receptor (PTGIR)
    Andere Bezeichnung
    Prostaglandin I2 Receptor (PTGIR Produkte)
    Synonyme
    IP antikoerper, PGI2 antikoerper, PRIPR antikoerper, prostaglandin I receptor (IP) antikoerper, prostaglandin I2 receptor antikoerper, Ptgir antikoerper, PTGIR antikoerper
    Hintergrund

    Synonyms: IP, PGI receptor, PGI2 receptor, PI2R_HUMAN, PRIPR, Prostacyclin receptor, Prostaglandin I2 receptor, Prostanoid IP receptor, PTGIR.

    Background: Cyclooxygenases metabolize arachidonate to five primary prostanoids: PGE2, PGF2?, PGI2, TXA2 and PGD2. These lipid mediators interact with specific members of G protein-coupled prostanoid receptors, designated EP, FP, IP, TP and DP, respectively. The IP Receptor binds prostacyclin, PGI2, the main pro-stanoid synthesized by vascular tissues.Upon binding to the IP Receptor, prostacyclin activates adenylate cyclase primarily through the Gas protein. The gene encoding the human IP Receptor is located on chromosome 19. It is expressed as a glycosylated and phosphorylated protein, which is abundantly expressed in vascular tissues such as aorta, lung, atrium and ventricle, as well as in kidney, thymus, spleen and neurons.

    Pathways
    cAMP Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling
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