ATXN7 Antikörper (AA 301-400) (AbBy Fluor® 488)

Produktnummer ABIN1390558

Produktdetails anti-ATXN7 Antikörper (AbBy Fluor® 488)

Target: ATXN7 (Ataxin 7 (ATXN7))

Bindungsspezifität: AA 301-400

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATXN7 Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Cow,Sheep,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Ataxin 7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu ATXN7

Target: ATXN7 (Ataxin 7 (ATXN7))

Andere Bezeichnung: Ataxin 7 (ATXN7 Produkte)

Synonyme: MGC82940 antikoerper, ADCAII antikoerper, OPCA3 antikoerper, SCA7 antikoerper, A430107N12Rik antikoerper, AI627028 antikoerper, Sca7 antikoerper, ataxin-7 antikoerper, RGD1562692 antikoerper, ataxin 7 L homeolog antikoerper, ataxin 7 antikoerper, atxn7.L antikoerper, atxn7 antikoerper, ATXN7 antikoerper, Atxn7 antikoerper

Hintergrund:

Synonyms: Ataxin7, Ataxin-7, ADCAII, ATXN 7, OPCA III, OPCA3, SCA 7, SCA7, Spinocerebellar Ataxia 7, Spinocerebellar ataxia type 7 protein, ATX7_HUMAN.

Background: The human ataxin-7 gene, also known as spinocerebellar ataxia 7 or SCA7, maps to chromosome 3p13-p12, has a 2,727-bp open reading frame, and encodes a 892 amino acid protein containing a nuclear localization signal and a polyglutamine tract (1,2). SCA7 is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss caused by the expansion of a translated CAG repeat encoding a polyglutamine tract in ataxin-7, which is the SCA7 gene product (3,4). Ataxin-7 is expressed within neurons both affected and unaffected in SCA7 pathology with subcellular localization being variable depending upon the neuronal subtype (5). Polyglutamine expanded in ataxin-7 may carry out its pathogenic effects in the nucleus by altering the matrix-associated nuclear structure and/or by disrupting nucleolar function (6).