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Complexin 1 Antikörper (AA 31-100) (AbBy Fluor® 647)

CPLX1 Reaktivität: Maus, Ratte WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 647
Produktnummer ABIN1390698
  • Target Alle Complexin 1 (CPLX1) Antikörper anzeigen
    Complexin 1 (CPLX1)
    Bindungsspezifität
    • 14
    • 14
    • 8
    • 7
    • 6
    • 6
    • 1
    • 1
    AA 31-100
    Reaktivität
    • 36
    • 25
    • 23
    Maus, Ratte
    Wirt
    • 49
    • 1
    • 1
    • 1
    Kaninchen
    Klonalität
    • 52
    Polyklonal
    Konjugat
    • 15
    • 6
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Complexin 1 Antikörper ist konjugiert mit AbBy Fluor® 647
    Applikation
    • 36
    • 22
    • 20
    • 12
    • 12
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Maus, Ratte
    Homologie
    Human,Cow,Pig,Chicken
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CPLX1
    Isotyp
    IgG
    Top Product
    Discover our top product CPLX1 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    Complexin 1 (CPLX1)
    Andere Bezeichnung
    CPLX1 (CPLX1 Produkte)
    Synonyme
    MGC84299 antikoerper, CPLX1 antikoerper, CPX-I antikoerper, CPX1 antikoerper, 921-S antikoerper, complexin 1 L homeolog antikoerper, complexin 1 antikoerper, cplx1.L antikoerper, CPLX1 antikoerper, cplx1 antikoerper, Cplx1 antikoerper
    Hintergrund

    Synonyms: complexin 1, Complexin I, Complexin-1, CPLX1, CPLX1_HUMAN, CPX I, CPX-I, CPX1, Synaphin 2, Synaphin-2, 921-S.

    Background: Complexin 1 and Complexin 2, also designated Synaphin 1 and Synaphin 2, contain an a-helical middle domain of approximately 58 amino acids. Complexin 1 and Complexin 2 are expressed in presynaptic terminals of inhibitory and excitatory hippocampal neurons, respectively, and in cytoplasmic pools during early stages of development. Complexins promote SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) precomplex formation by binding to synaxin with its a-helical domain. Complexins are important regulators of transmitter release at a late step in calcium dependent neurotransmitter release or immediately after the calcium-triggering step of fast synchronous transmitter release and preceding vesicle fusion. Neurons lacking complexins show reduced transmitter release efficiency due to decreased calcium sensitivity of the synaptic secretion process. Complexin 2 may play a role in LTP (long term potentiation) following tetanic stimulation. A progressive loss of Complexin 2 occurs in the brains of mice carrying the Huntington disease mutation, an autosomal dominant neurodegenerative disorder. Changes in the neurotransmitter release might contribute to the motor, emotional and cognitive dysfunctions seen in these mice.

    Pathways
    Hormone Transport, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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