UNC5D Antikörper (AA 112-200) (AbBy Fluor® 555)
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- Target Alle UNC5D Antikörper anzeigen
- UNC5D (Unc-5 Homolog D (UNC5D))
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Bindungsspezifität
- AA 112-200
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser UNC5D Antikörper ist konjugiert mit AbBy Fluor® 555
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Applikation
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Homologie
- Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human UNC5H4
- Isotyp
- IgG
- Top Product
- Discover our top product UNC5D Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- UNC5D (Unc-5 Homolog D (UNC5D))
- Andere Bezeichnung
- UNC5D/UNC5H4 (UNC5D Produkte)
- Synonyme
- UNC5D antikoerper, PRO34692 antikoerper, Unc5h4 antikoerper, D930029E11Rik antikoerper, mKIAA1777 antikoerper, unc-5 netrin receptor D antikoerper, unc-5 homolog D (C. elegans) antikoerper, Unc5d antikoerper, UNC5D antikoerper, unc5d antikoerper
- Hintergrund
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Synonyms: Netrin receptor UNC5D, Netrin receptor Unc5h4, Protein unc 5 homolog D, Unc 5 homolog 4, Unc 5 homolog D C. elegans, Unc 5 homolog D, UNC 5D, Unc5h4, FLJ16019, KIAA1777.
Background: The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is down-regulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. UNC5H4, also known as UNC5D (unc-5 homolog D), is single-pass type I membrane protein that is a member of the UNC5H netrin receptor family. Two isoforms of UNC5H4 exist due to alternative splicing events.
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