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UNC5A Antikörper (AA 125-220) (Biotin)

UNC5A Reaktivität: Human ELISA, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN1391605
  • Target Alle UNC5A Antikörper anzeigen
    UNC5A (Unc-5 Homolog A (UNC5A))
    Bindungsspezifität
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 125-220
    Reaktivität
    • 28
    • 13
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 28
    • 1
    Kaninchen
    Klonalität
    • 28
    • 1
    Polyklonal
    Konjugat
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser UNC5A Antikörper ist konjugiert mit Biotin
    Applikation
    • 13
    • 13
    • 7
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Unc5a
    Isotyp
    IgG
    Top Product
    Discover our top product UNC5A Primärantikörper
  • Applikationshinweise
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    UNC5A (Unc-5 Homolog A (UNC5A))
    Andere Bezeichnung
    Unc5a/UNC5H1 (UNC5A Produkte)
    Synonyme
    zgc:175190 antikoerper, UNC5H1 antikoerper, Unc5h1 antikoerper, mKIAA1976 antikoerper, unc-5 netrin receptor A antikoerper, netrin receptor UNC5A antikoerper, UNC5A antikoerper, Tsp_02512 antikoerper, Tsp_13881 antikoerper, unc5a antikoerper, Unc5a antikoerper
    Hintergrund

    Synonyms: Netrin receptor UNC 5A, Netrin receptor UNC5A, Netrin receptor Unc5h1, Protein unc-5 homolog 1, Protein unc-5 homolog A, Unc 5 homolog 1, Unc 5 homolog A, Unc 5a, Unc5 a, Unc5 homolog 1, Unc5 homolog A, Unc5a, UNC5A_HUMAN, Unc5h1, FLJ16449, KIAA1976.

    Background: The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is downregulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung and kidney cancers. UNC5H1, also known as UNC5HA (unc-5 homolog A), is a member of the UNC5H family of proteins and is localized to the cell membrane. Three isoforms of UNC5H1 exist due to alternative splicing events.

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