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BBS4 Antikörper (AA 431-519) (AbBy Fluor® 350)

BBS4 Reaktivität: Maus WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 350
Produktnummer ABIN1391679
  • Target Alle BBS4 Antikörper anzeigen
    BBS4 (Bardet-Biedl Syndrome 4 (BBS4))
    Bindungsspezifität
    • 14
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 431-519
    Reaktivität
    • 23
    • 19
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Maus
    Wirt
    • 26
    • 5
    • 2
    Kaninchen
    Klonalität
    • 30
    • 3
    Polyklonal
    Konjugat
    • 20
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BBS4 Antikörper ist konjugiert mit AbBy Fluor® 350
    Applikation
    • 33
    • 12
    • 12
    • 8
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Maus
    Homologie
    Human,Rat,Dog,Cow,Sheep,Pig,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human BBS4
    Isotyp
    IgG
    Top Product
    Discover our top product BBS4 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    BBS4 (Bardet-Biedl Syndrome 4 (BBS4))
    Andere Bezeichnung
    BBS4 (BBS4 Produkte)
    Synonyme
    CG13232 antikoerper, Dmel\\CG13232 antikoerper, zgc:152964 antikoerper, AW537059 antikoerper, AW742241 antikoerper, D9Ertd464e antikoerper, Bardet-Biedl syndrome 4 antikoerper, bardet-biedl syndrome 4 antikoerper, Bardet-Biedl syndrome 4 (human) antikoerper, BBS4 antikoerper, bbs4 antikoerper, Bbs4 antikoerper
    Hintergrund

    Synonyms: Bardet Biedl syndrome 4 protein, Bardet-Biedl syndrome 4 protein, Bbs4, BBS4_HUMAN.

    Background: Bardet-Biedl syndrome (BBS) is a pleiotropic genetic disorder characterized by obesity, photoreceptor degeneration, polydactyly, hypogenitalism, renal abnormalities, and developmental delay. Other associated clinical findings in BBS patients include diabetes, hypertension, and congenital heart defects. BBS is a heterogeneous disorder, BBS genes map to eight genetic loci and encode eight proteins, BBS1-BBS8. Five BBS genes encode basal body or cilia proteins, suggesting that BBS is a ciliary dysfunction disorder. BBS4 is expressed in the olfactory epithelium and localizes to the centriolar satellites of centrosomes and basal bodies of primary cilia. BBS4 regulates the p150 subunit of the dynein transport machinery (DCTN1) to attract pericentriolar material-1 protein (PCM1) and its associated components to the satellites. Loss of BBS4 is correlated with obesity caused by abnormal lipid profiles, liver dysfunction, elevated insulin, and abnormal leptin levels.

    Pathways
    Hedgehog Signalweg, Tube Formation, Maintenance of Protein Location
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