CALHM1 Antikörper (AA 161-260) (Biotin)

Produktnummer ABIN1392481

Produktdetails anti-CALHM1 Antikörper (Biotin)

Target: CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))

Bindungsspezifität: AA 161-260

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CALHM1 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Cow,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CALHM1/FAM26C

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu CALHM1

Target: CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))

Andere Bezeichnung: CALHM1/FAM26C (CALHM1 Produkte)

Synonyme: FAM26C antikoerper, Fam26c antikoerper, RGD1564891 antikoerper, EG546729 antikoerper, calcium homeostasis modulator 1 antikoerper, novel protein similar to vertebrate calcium homeostasis modulator protein family antikoerper, CALHM1 antikoerper, LOC557535 antikoerper, Calhm1 antikoerper

Hintergrund:

Synonyms: CAHM1_HUMAN, Calcium homeostasis modulator 1, Calcium homeostasis modulator protein 1, CALHM1, FAM26C, Family with sequence similarity 26, member C, MGC39514, MGC39617, Protein FAM26C.

Background: CALHM1 is a 346 amino acid multi-pass endoplasmic reticulum membrane protein that belongs to the FAM26 family. CALHM1 co-localizes with GRP 78 to the endoplasmic reticulum. Predominantly expressed in adult brain, CALHM1 may be a pore-forming ion channel that controls cytosolic Ca2+ permeability and cytosolic Ca2+ concentration in the cell. It is suggested that CALHM1 regulates amyloid precursor protein proteolysis and aggregated amyloid-beta peptides levels in a Ca2+ dependent manner. CALHM1 homomultimerizes and shares strong sequence similarities with the selectivity filter of the NMDA receptor, which generates a large Ca2+ conductance across the plasma membrane. CALHM1 may be a potential factor involved in the pathogenesis of Alzheimer's disease.