SH3PXD2A Antikörper (AA 261-360) (Biotin)

Produktnummer ABIN1392499

Produktdetails anti-SH3PXD2A Antikörper (Biotin)

Target: SH3PXD2A (SH3 and PX Domains 2A (SH3PXD2A))

Bindungsspezifität: AA 261-360

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SH3PXD2A Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Ratte

Homologie: Human,Mouse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FISH

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu SH3PXD2A

Target: SH3PXD2A (SH3 and PX Domains 2A (SH3PXD2A))

Andere Bezeichnung: FISH (SH3PXD2A Produkte)

Synonyme: FISH antikoerper, SH3MD1 antikoerper, TKS5 antikoerper, 2310014D11Rik antikoerper, AA589508 antikoerper, AI256723 antikoerper, AI413738 antikoerper, C230050L11 antikoerper, EG329070 antikoerper, Fish antikoerper, Gm5098 antikoerper, Sh3md1 antikoerper, TSK5 antikoerper, Tks5 antikoerper, sh3pxd2a antikoerper, si:dkey-82d4.2 antikoerper, SH3 and PX domains 2A antikoerper, SH3 and PX domains 2Aa antikoerper, SH3PXD2A antikoerper, Sh3pxd2a antikoerper, sh3pxd2aa antikoerper

Hintergrund:

Synonyms: Adapter protein TKS5, Five SH3 domain-containing protein, SH3 and PX domain-containing protein 2A, SH3 multiple domains protein 1, Sh3md1, Sh3pxd2a, SPD2A_HUMAN, TKs5, Tyrosine kinase substrate with five SH3 domains.

Background: Fish, a potential Src substrate, is a broadly expressed adaptor protein containing five SH3 domains and a phox homology (PX) domain (1). The Src family of protein tyrosine kinases act in signal transduction pathways (2-4). Src kinases vary in expression but are strongly regulated in vivo, catalytic activity is repressed by interacting with the SH3 domain (5-7). In Src-transformed fibroblasts and in normal cells treated with certain growth factors fish is tyrosine-phosphorylated (1). Treatment of cells with cytochalasin D results in rapid tyrosine phosphorylation of fish, along with activation of Src (1). Fish is likely to be involved in tyrosine kinase signaling and may have a role in cytoskeletal changes (1).