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Senataxin (SETX) (AA 321-398) Antikörper (AbBy Fluor® 350)

SETX Reaktivität: Maus WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 350
Produktnummer ABIN1392777
  • Target Alle Senataxin (SETX) Antikörper anzeigen
    Senataxin (SETX)
    Bindungsspezifität
    • 14
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 321-398
    Reaktivität
    • 14
    • 11
    • 1
    Maus
    Wirt
    • 23
    • 2
    Kaninchen
    Klonalität
    • 22
    • 3
    Polyklonal
    Konjugat
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AbBy Fluor® 350
    Applikation
    • 20
    • 12
    • 12
    • 9
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Maus
    Homologie
    Human,Rat,Dog,Cow,Sheep,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Senataxin
    Isotyp
    IgG
    Top Product
    Discover our top product SETX Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    Senataxin (SETX)
    Andere Bezeichnung
    Senataxin/SETX (SETX Produkte)
    Synonyme
    ALS4 antikoerper, SETX antikoerper, wu:fj92h09 antikoerper, AOA2 antikoerper, SCAR1 antikoerper, bA479K20.2 antikoerper, Als4 antikoerper, Sen1 antikoerper, AW060766 antikoerper, mKIAA0625 antikoerper, A130090N03 antikoerper, A930037J23Rik antikoerper, RGD1565575 antikoerper, senataxin antikoerper, SETX antikoerper, setx antikoerper, Setx antikoerper
    Hintergrund

    Synonyms: ALS4, AOA2, SCAR1, bA479K20.2, Probable helicase senataxin, Amyotrophic lateral sclerosis 4 protein, SEN1 homolog, Senataxin, SETX, KIAA0625

    Background: Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111).

    Gen-ID
    23064
    UniProt
    Q7Z333
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