Coagulation Factor VIII-Associated 1 (F8A1) (AA 2-80) Antikörper (Biotin)

Produktnummer ABIN1392799

Produktdetails

Target: Coagulation Factor VIII-Associated 1 (F8A1)

Bindungsspezifität: AA 2-80

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: Human,Mouse,Rat,Cow

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HAP40

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Antigendetails

Target: Coagulation Factor VIII-Associated 1 (F8A1)

Andere Bezeichnung: HAP40/F8a (F8A1 Produkte)

Synonyme: DXS522E antikoerper, F8A antikoerper, HAP40 antikoerper, F8a antikoerper, Hap40 antikoerper, RGD1566014 antikoerper, f8a antikoerper, f8a1 antikoerper, hap40 antikoerper, dxs522e antikoerper, MGC147036 antikoerper, coagulation factor VIII associated 1 antikoerper, coagulation factor VIII-associated 1 antikoerper, coagulation factor VIII antikoerper, F8A1 antikoerper, F8a1 antikoerper, f8a1 antikoerper

Hintergrund:

Synonyms: Coagulation factor 8 associated intronic transcript 1, Coagulation factor VIII associated intronic transcript 1, CpG island protein, DXS522E, F8a, F8A1, F8A2, F8A3, Factor 8 associated protein, Factor 8 intron 22 protein, Factor VIII associated protein, Factor VIII intron 22 protein, huntingtin associated protein 40, F8I2_HUMAN.

Background: The Huntingtin protein contains a polyglutamine region, which leads to Huntingtin?s disease (HD) when the number of glutamine repeats exceeds thirty-five. The mutated Huntingtin protein acts within the nucleus to induce neurodegeneration by a cell-specific apoptotic mechanism. The loss of activity of the Huntingtin protein may be contributed to abnormal interactions between the mutant protein and other associated cellular proteins. Huntingtin interacts with a variety of proteins including HAP1, glyceraldehyde phosphate dehydrogenase (GAPDH), HAP40, Rab5 and HIP1. HAP40 mediates the recruitment of Huntingtin by Rab5 onto early endosomes. Specifically, this complex regulates endosome motility, which may be a key event of the pathogenetic process leading to neurodegeneration in HD.