IFT57 Antikörper (AA 331-429) (Biotin)

Produktnummer ABIN1392805

Produktdetails anti-IFT57 Antikörper (Biotin)

Target: IFT57 (Intraflagellar Transport 57 Homolog (IFT57))

Bindungsspezifität: AA 331-429

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IFT57 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HIPPI

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu IFT57

Target: IFT57 (Intraflagellar Transport 57 Homolog (IFT57))

Andere Bezeichnung: HIPPI (IFT57 Produkte)

Synonyme: Esrrbl1 antikoerper, 4833420A15Rik antikoerper, Hippi antikoerper, MHS4R2 antikoerper, ESRRBL1 antikoerper, HIPPI antikoerper, intraflagellar transport 57 antikoerper, intraflagellar transport 57 S homeolog antikoerper, Ift57 antikoerper, IFT57 antikoerper, ift57.S antikoerper

Hintergrund:

Synonyms: Dermal papilla derived protein 8, Dermal papilla-derived protein 8, DERP 8, DERP8, Esrrbl 1, Esrrbl1, ESRRBL1 protein, Estrogen related receptor beta like 1, Estrogen related receptor beta like protein 1, Estrogen-related receptor beta like 1, Estrogen-related receptor beta-like protein 1, FLJ10147, Hip1 Interacting Protein, HIP1 interacting protein HIPPI, Hip1 protein interactor, HIP1-interacting protein, HIPPI, Huntingtin interacting protein 1 interacting protein, Huntingtin interacting protein 1 protein interactor, Huntingtin-interacting protein-1 protein interactor, T 57, t57, T57_HUMAN, Intraflagellar transport 57 homolog Chlamydomonas, Intraflagellar transport 57 homolog, Intraflagellar transport protein 57 homolog, MHS4R2, Vestrogen related receptor beta like 1, Vestrogen-related receptor beta like 1, CDNA FLJ10147 fis clone HEMBA1003369.

Background: Programmed neuronal cell death is a feature of neurodegenerative disorders such as Alzheimer's and Huntington's disease, which occur later in human life. Huntington?s disease at the molecular and cell level is characterized by polyglutamine expansion of the protein huntingtin (Htt) that leads to apoptotis-mediated neurodegenerative loss of medium spiny neurons throughout the striatum. Polyglutamine expansion reduces the level of association between Hip-1 and Htt, thereby increasing levels of free Hip-1 that then can be the candidate protein Hippi (Hip-1 protein interactor). The Hippi-Hip-1 heterodimer is a pro-apoptotic complex that recruits procaspase-8 and initiates caspase-8 activation, which may contribute to the neuronal cell death observed in individuals diagnosed with Huntington?s disease. The human hippi gene maps to chromosome 3q13.13 and encodes a 429 amino acid protein.

Pathways: Hedgehog Signalweg, Positive Regulation of Endopeptidase Activity