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ALS2 Antikörper (AA 1384-1440) (Biotin)

ALS2 Reaktivität: Human ELISA, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN1392877
  • Target Alle ALS2 Antikörper anzeigen
    ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))
    Bindungsspezifität
    • 14
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1384-1440
    Reaktivität
    • 43
    • 11
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 40
    • 3
    • 1
    Kaninchen
    Klonalität
    • 41
    • 2
    Polyklonal
    Konjugat
    • 25
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ALS2 Antikörper ist konjugiert mit Biotin
    Applikation
    • 21
    • 13
    • 13
    • 13
    • 7
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human ALS2
    Isotyp
    IgG
    Top Product
    Discover our top product ALS2 Primärantikörper
  • Applikationshinweise
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))
    Andere Bezeichnung
    ALS2/Alsin (ALS2 Produkte)
    Synonyme
    als2 antikoerper, si:dkey-33m14.1 antikoerper, ALS2CR6 antikoerper, ALSJ antikoerper, IAHSP antikoerper, PLSJ antikoerper, 3222402C23Rik antikoerper, 9430073A21Rik antikoerper, Als2cr6 antikoerper, Alsin antikoerper, mKIAA1563 antikoerper, amyotrophic lateral sclerosis 2a (juvenile) antikoerper, alsin antikoerper, ALS2, alsin Rho guanine nucleotide exchange factor antikoerper, amyotrophic lateral sclerosis 2 (juvenile) antikoerper, als2a antikoerper, CpipJ_CPIJ008258 antikoerper, CpipJ_CPIJ008260 antikoerper, ALS2 antikoerper, Als2 antikoerper
    Hintergrund

    Synonyms: ALS 2, ALS2, ALS2_HUMAN, ALS2CR6, Alsin, ALSJ, Amyotrophic lateral sclerosis 2 juvenile, Amyotrophic lateral sclerosis 2 juvenile chromosome region candidate 6, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein, Amyotrophic lateral sclerosis 2 protein, Amyotrophic lateral sclerosis protein 2, FLJ31851, IAHSP, KIAA1563, MGC87187, PLSJ.

    Background: Mutations in the ALS2 gene result in a number of juvenile recessive motor neuron diseases (MNDs), including juvenile primary lateral sclerosis (JPLS), a recessive form of amyotrophic lateral sclerosis (ALS2), infantile onset ascending hereditary spastic paralysis (IAHSP), and a form of complicated hereditary spastic paraplegia (cHSP). The ALS2 gene encodes the Alsin protein. Alsin acts as a guanine nucleotide exchange factor for Rab5, a modulator of the endocytic pathway. Alsin is a cytosolic protein that is associated with small, punctate membrane structures. Therefore, Alsin may mediate membrane transport events, potentially linking endocytic processes and actin cytoskeleton remodeling. The ALS2 C-terminal-like protein (ALS2CL) also modulates Rab 5 activity.

    Pathways
    Skeletal Muscle Fiber Development
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