EN1 Antikörper (AA 351-392) (Biotin)

Produktnummer ABIN1393069

Produktdetails anti-EN1 Antikörper (Biotin)

Target: EN1 (Engrailed Homeobox 1 (EN1))

Bindungsspezifität: AA 351-392

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EN1 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Sheep,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EN1/Engrailed 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu EN1

Target: EN1 (Engrailed Homeobox 1 (EN1))

Andere Bezeichnung: EN1/Engrailed 1 (EN1 Produkte)

Synonyme: EN1 antikoerper, En-1 antikoerper, Mo-en.1 antikoerper, ENG-1 antikoerper, en-1 antikoerper, en1 antikoerper, eng1 antikoerper, zgc:100771 antikoerper, en1-A antikoerper, engrailed-1 antikoerper, xen1 antikoerper, Gg-En-1 antikoerper, en-3 antikoerper, engrailed antikoerper, engrailed homeobox 1 antikoerper, engrailed 1 antikoerper, engrailed homeobox 1a antikoerper, engrailed homeobox 1 S homeolog antikoerper, EN1 antikoerper, En1 antikoerper, en1a antikoerper, en1.S antikoerper

Hintergrund:

Synonyms: En 1, EN1, Engrailed 1, Engrailed, Engrailed homeobox 1, Engrailed homolog 1, HME1_HUMAN, Homeobox protein en-1, Homeobox protein engrailed 1, Homeobox protein engrailed-1, Hu-En-1, Mo-en.1.

Background: The engrailed-1 gene, EN1, a murine homolog of the Drosophila homeobox gene engrailed (EN), is required for midbrain and cerebellum development and dorsal/ventral patterning of the limbs as well as apical ectodermal ridge formation. In Drosophila, the EN gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Human EN-1 and EN-2 are homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. Different mutations in the mouse homo-logs, EN-1 and EN-2, produce different developmental defects that frequently are lethal. EN-1 is highly expressed by essentially all dopaminergic neurons in the substantia nigra and ventral tegmentum. EN-1 and EN-2 regulate expres-sion of a-synuclein, a gene that is genetically linked to Parkinson?s disease.

Gen-ID: 2019

UniProt: Q05925

Pathways: Dopaminergic Neurogenesis