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TIMM8A/DDP Antikörper (AA 31-97) (Biotin)

TIMM8A Reaktivität: Human ELISA, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN1393213
  • Target Alle TIMM8A/DDP (TIMM8A) Antikörper anzeigen
    TIMM8A/DDP (TIMM8A) (Translocase of Inner Mitochondrial Membrane 8A (TIMM8A))
    Bindungsspezifität
    • 14
    • 4
    • 2
    • 1
    • 1
    • 1
    AA 31-97
    Reaktivität
    • 33
    • 10
    • 9
    • 1
    • 1
    Human
    Wirt
    • 28
    • 5
    Kaninchen
    Klonalität
    • 30
    • 3
    Polyklonal
    Konjugat
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TIMM8A/DDP Antikörper ist konjugiert mit Biotin
    Applikation
    • 13
    • 13
    • 9
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Homologie
    Human,Mouse,Rat,Cow,Sheep,Pig
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human TIMM8A
    Isotyp
    IgG
    Top Product
    Discover our top product TIMM8A Primärantikörper
  • Applikationshinweise
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    TIMM8A/DDP (TIMM8A) (Translocase of Inner Mitochondrial Membrane 8A (TIMM8A))
    Andere Bezeichnung
    TIMM8A (TIMM8A Produkte)
    Synonyme
    TIMM8A antikoerper, ddp antikoerper, tim8a antikoerper, timm8a antikoerper, DDP antikoerper, DDP1 antikoerper, DFN1 antikoerper, MTS antikoerper, TIM8 antikoerper, im:6896085 antikoerper, zgc:100916 antikoerper, Ddp1 antikoerper, Timm8a antikoerper, DXHXS1274E antikoerper, Fci-12 antikoerper, Tim8a antikoerper, translocase of inner mitochondrial membrane 8 homolog A (yeast) antikoerper, translocase of inner mitochondrial membrane 8A antikoerper, translocase of inner mitochondrial membrane 8 homolog A1 (yeast) antikoerper, translocase of inner mitochondrial membrane 8A1 antikoerper, TIMM8A antikoerper, timm8a antikoerper, Timm8a1 antikoerper
    Hintergrund

    Synonyms: DDP 1, DDP, DDP1, Deafness dystonia protein 1, Deafness/dystonia peptide, DFN 1, DFN1, MGC12262, Mitochondrial import inner membrane translocase subunit Tim8 A, MTS, TIM 8A, TIM8A, TIMM 8A, Translocase of inner mitochondrial membrane 8 homolog A, X linked deafness dystonia protein, TIM8A_HUMAN.

    Background: The majority of mitochondrial-directed proteins are encoded by the nuclear genome and are transported to the mitochondria via regulated processes involving the mitochondrial Tom and Tim proteins (1). The mitochondrial Tim protein family is comprised of a large group of evolutionarily conserved proteins that are found in most eukaryotes (1,2). Import of nuclear-encoded precursor proteins into and across the mitochondrial inner membrane is mediated by two distinct complexes, the Tim23 complex and the Tim22 complex, which differ in their substrate specificity (1). Defects in Tim proteins are implicated in several neuro-degenerative diseases, suggesting important roles for Tim proteins in development and health (3,4). Tim8A and Tim8B, which map to human chromosomes Xq22.1 and 11q23.1-q23.2, respectively, are conserved proteins of the mitochondrial intermembrane space, which are organized in hetero-oligomeric complex with Tim13 (5,6,7). Tim8A is highly expressed in fetal and adult brain (5). Tim8A is mutated in deafness dystonia syndrome, a novel type of disease that causes severe neurological defects, thought to be caused by a defective mitochondrial protein transport system (5,8).

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