ZFYVE27 Antikörper (AA 341-411) (Biotin)

Produktnummer ABIN1393261

Produktdetails anti-ZFYVE27 Antikörper (Biotin)

Target: ZFYVE27 (Zinc Finger, FYVE Domain Containing 27 (ZFYVE27))

Bindungsspezifität: AA 341-411

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZFYVE27 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ZFYVE27

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu ZFYVE27

Target: ZFYVE27 (Zinc Finger, FYVE Domain Containing 27 (ZFYVE27))

Andere Bezeichnung: ZFYVE27 (ZFYVE27 Produkte)

Synonyme: ZFYVE27 antikoerper, MGC130947 antikoerper, spg33 antikoerper, im:7137347 antikoerper, zgc:153156 antikoerper, PROTRUDIN antikoerper, RP11-459F3.2 antikoerper, SPG33 antikoerper, 2210011N02Rik antikoerper, 9530077C24Rik antikoerper, AI426636 antikoerper, AI593546 antikoerper, AI835681 antikoerper, zinc finger FYVE-type containing 27 antikoerper, zinc finger FYVE domain containing 27 L homeolog antikoerper, zinc finger FYVE domain containing 27 antikoerper, zinc finger, FYVE domain containing 27 antikoerper, ZFYVE27 antikoerper, zfyve27.L antikoerper, zfyve27 antikoerper, Zfyve27 antikoerper

Hintergrund:

Synonyms: Protrudin, RP11 459F3.2, SPG33, ZFY27_HUMAN, ZFYVE27, zinc finger FYVE domain containing 27, Zinc finger FYVE domain containing protein 27, Zinc finger FYVE domain-containing protein 27.

Background: Zinc finger FYVE domain-containing protein 27 (ZFYVE27), also known as SPG33, is a 411 amino acid member of the FYVE-finger family of proteins. The FYVE domain is a cysteine-rich domain of about 70 amino acids that plays a role in the endosomal localization of the FYVE-finger proteins, and a majority of these proteins serve as regulators of endocytic membrane trafficking. ZFYVE27, a multi-pass membrane protein, is an endosomal protein that binds to Spastin, a protein that is primarily involved in microtubule dynamics and severing, vesicular trafficking and endosomal trafficking. Mutations in the gene encoding ZFTVE27 affect neuronal intracellular trafficking in the corticospinal tract and are thought to lead to hereditary spastic paraplegia (HSP), a neurodegenerative disorder, characterized by progressive paralysis of the legs, which is caused by impaired axonal transport. Five isoforms of ZFYVE27 exist as a result of alternative splicing events.

Gen-ID: 118813

UniProt: Q5T4F4

Pathways: Neurotrophin Signalübertragung