Ataxin 10 Antikörper (AA 21-120) (Biotin)

Produktnummer ABIN1393435

Produktdetails anti-Ataxin 10 Antikörper (Biotin)

Target: Ataxin 10 (ATXN10)

Bindungsspezifität: AA 21-120

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ataxin 10 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Cow,Sheep,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ATXN10/SCA10

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu Ataxin 10

Target: Ataxin 10 (ATXN10)

Andere Bezeichnung: ATXN10/SCA10 (ATXN10 Produkte)

Synonyme: ATXN10 antikoerper, MGC97716 antikoerper, atxn10 antikoerper, Ataxin-10 antikoerper, si:dkeyp-15g12.2 antikoerper, E46L antikoerper, HUMEEP antikoerper, SCA10 antikoerper, Sca10 antikoerper, AI325283 antikoerper, C77170 antikoerper, E46 antikoerper, TEG-169 antikoerper, Tex169 antikoerper, ataxin 10 antikoerper, ATXN10 antikoerper, atxn10 antikoerper, Atxn10 antikoerper

Hintergrund:

Synonyms: Ataxin 10, Ataxin-10, ATX10_HUMAN, Atxn10, Brain protein E46 homolog, E46L, FLJ37990, HUMEEP, Like mouse brain protein E46, SCA10, Spinocerebellar ataxia 10, Spinocerebellar ataxia type 10 protein.

Background: Spinocerebellar ataxia (SCA) is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss. SCA is caused by the expansion of a translated CAG repeat, encoding a polyglutamine tract in SCA gene products, known as ataxins. The ataxin proteins are ubiquitously expressed in nervous tissue, but are primarily detected in cerebellum, brain stem and spinal cord in the central nervous system. Ataxin-10 is a cytoplasmic protein that belongs to the family of armadillo repeat proteins. A loss of ataxin-10 in primary neuronal cells causes increased apoptosis of cerebellar neurons. Ataxin-10 interacts with p110, an O-Linked beta-N-acetylglucosamine transferase, and may be important in the regulation of intracellular glycosylation levels and homeostasis in the brain. Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant disorder that causes cerebellar ataxia and seizures. SCA10 is caused by an expansion of an ATTCT pentanucleotide repeat in intron 9 of the ataxin-10 gene.