KALRN Antikörper (AA 1401-1500) (AbBy Fluor® 488)

Produktnummer ABIN1393756

Produktdetails anti-KALRN Antikörper (AbBy Fluor® 488)

Target: KALRN (Kalirin, RhoGEF Kinase (KALRN))

Bindungsspezifität: AA 1401-1500

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KALRN Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KALRN/Duo

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu KALRN

Target: KALRN (Kalirin, RhoGEF Kinase (KALRN))

Andere Bezeichnung: KALRN/Duo (KALRN Produkte)

Synonyme: ARHGEF24 antikoerper, CHD5 antikoerper, CHDS5 antikoerper, DUET antikoerper, DUO antikoerper, HAPIP antikoerper, TRAD antikoerper, KALRN antikoerper, 2210407G14Rik antikoerper, AV235988 antikoerper, E530005C20Rik antikoerper, Gm539 antikoerper, Hapip antikoerper, Duo antikoerper, Kalirin antikoerper, kalirin RhoGEF kinase antikoerper, kalirin, RhoGEF kinase antikoerper, kalirin antikoerper, kalirin RhoGEF kinase L homeolog antikoerper, putative kalirin antikoerper, KALRN antikoerper, LOC460643 antikoerper, Kalrn antikoerper, kalrn antikoerper, kalrn.L antikoerper, LOC100473997 antikoerper, Smp_162970 antikoerper

Hintergrund:

Synonyms: Duo, FLJ16443, HAPIP, Huntingtin associated protein interacting protein duo , Huntingtin-associated protein-interacting protein, Kalirin isoform 2, Kalirin, KALRN , KALRN_HUMAN , Protein Duo, RhoGEF kinase, Serine/threonine kinase with Dbl and pleckstrin homology domains , Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain, TRAD.

Background: HAP1 (huntingtin-associated protein 1) binds to huntingtin (1). Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington?s disease (HD) (2,3). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region (1). HAP1 shows neuronal localization and moves with huntingtin in nerve fibers (4,5). HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem (1). Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons (6). Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.

Pathways: Neurotrophin Signalübertragung