KIAA0319 Antikörper (AA 682-760) (AbBy Fluor® 488)

Produktnummer ABIN1393762

Produktdetails anti-KIAA0319 Antikörper (AbBy Fluor® 488)

Target: KIAA0319

Bindungsspezifität: AA 682-760

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIAA0319 Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Cow,Sheep,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DYX2/KIAA0319

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu KIAA0319

Target: KIAA0319

Andere Bezeichnung: DYX2/KIAA0319 (KIAA0319 Produkte)

Synonyme: DYLX2 antikoerper, DYX2 antikoerper, 4930451E12Rik antikoerper, Kiaa0319 antikoerper, KIAA0319 antikoerper, RIKEN cDNA D130043K22 gene antikoerper, KIAA0319 ortholog antikoerper, similar to mKIAA0319 protein antikoerper, KIAA0319 antikoerper, D130043K22Rik antikoerper, RGD1307443 antikoerper

Hintergrund:

Synonyms: DLX 2, DLX2, DYLX 2, DYLX2, Dyslexia susceptibility 2, Dyslexia-associated protein KIAA0319 DYX 2, DYX2, K0319_HUMAN, Kiaa0319, MGC176717.

Background: DYX2 is a 1072 amino acid single-pass transmembrane protein that contains one MANSC domain and two PKD (Polycystic Kidney Disease) domains, which are usually found in the extracellular regions of proteins and are involved in protein-protein interactions. In DYX2, it is likely that its PKD domains mediate the interaction between neurons and glial fibers during neuronal migration. When overexpressed, this plasma membrane protein colocalizes with EEA1 (early endosome antigen 1) in large intracellular vesicles, suggesting that it is endocytosed and recycled. DYX2 is highly expressed in brain cortex, cerebellum, amygdala, putamen and hippocampus. Defects in the gene encoding DYX2 may be the cause of dyslexia type 2, a relatively common disorder that is characterized by reading performance impairment in the absence of sensory or neurologic disability. There are three isoforms of DYX2 that are produced as a result of alternative splicing events