LIM Domain Binding 1 Protein Antikörper (AA 10-100) (Biotin)

Produktnummer ABIN1393801

Produktdetails anti-LIM Domain Binding 1 Protein Antikörper (Biotin)

Target: LIM Domain Binding 1 Protein (LDB1) (LIM Domain Binding 1 (LDB1))

Bindungsspezifität: AA 10-100

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LIM Domain Binding 1 Protein Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LDB1/CLIM-2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu LIM Domain Binding 1 Protein

Target: LIM Domain Binding 1 Protein (LDB1) (LIM Domain Binding 1 (LDB1))

Andere Bezeichnung: LDB1/CLIM-2 (LDB1 Produkte)

Synonyme: CLIM2 antikoerper, NLI antikoerper, chi antikoerper, clim2 antikoerper, nli antikoerper, xldb1 antikoerper, ldb1 antikoerper, LDB1 antikoerper, ldb4 antikoerper, ldb4b antikoerper, LIM domain binding 1 antikoerper, LIM domain binding 1 L homeolog antikoerper, LIM-domain binding 1b antikoerper, LIM domain binding protein 1 antikoerper, LIM domain binding 1a antikoerper, Ldb1 antikoerper, LDB1 antikoerper, ldb1.L antikoerper, ldb1b antikoerper, xldb1 antikoerper, ldb1a antikoerper

Hintergrund:

Synonyms: Carboxyl Terminal LIM Domain Binding 2, Carboxyl-terminal LIM domain-binding protein 2, CLIM 2, CLIM-2, hLdb1, LDB-1, ldb1, LDB1_HUMAN, LIM Domain Binding 1, LIM domain binding factor CLIM2, LIM domain-binding factor CLIM2, LIM domain-binding protein 1, NLI, Nuclear LIM Domain Interactor, Nuclear LIM interactor antibodyxldb1.

Background: The LIM-only (LMO) proteins, LMO1 and LMO2, are nuclear factors that are characterized by a conserved LIM domain. The LIM domain consists of a cysteine-rich zinc-binding motif that is present in a variety of transcription factors, including the LIM homeobox (LHX) proteins expressed in the central nervous system and involved in cell differentiation. LMO1 and LMO2 are expressed in the adult CNS in a cell type-specific manner, where they are differentially regulated by neuronal activity and are involved in regulating the cellular differentiated phenotype of neurons. LMO2 lacks a specific DNA-binding homeobox domain but rather assembles into transcriptional regulatory complexes to mediate gene expression by interacting with the widely expressed nuclear LIM interactor (NLI). NLI, known also as CLIM-1, and the related protein CLIM-2, facilitate the formation of heteromeric LIM complexes and also enhance the nuclear retention of LIM proteins. LMO2 and the related protein LMO4 are expressed in thymic precursor cells. LMO4 is also expressed in mature T cells, cranial neural crest cells, somite, dorsal limb bud mesenchyme, motor neurons, and Schwann cell progenitors.

Pathways: Stem Cell Maintenance, Chromatin Binding