MAP3K4 Antikörper (AA 1351-1450) (Biotin)

Produktnummer ABIN1393891

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MAP3K4 in ELISA, IHC (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für MAP3K4 Antikörper (AA 1351-1450) (Biotin) (ABIN1393891)

Target: MAP3K4 (Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP3K4 Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-MAP3K4 Antikörper (Biotin)

Bindungsspezifität: AA 1351-1450

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MAP3K4/MEK kinase-4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu MAP3K4

Target: MAP3K4 (Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))

Andere Bezeichnung: MAP3K4/MEK kinase-4

Hintergrund:

Synonyms: FLJ42439, KIAA0213, M3K4_HUMAN, MAP three kinase 1, MAP3K4, MAPK/ERK kinase kinase 4, MAPKKK4 antibodyMEK kinase 4, MEKK 4, MEKK4, Mitogen-activated protein kinase kinase kinase 4, MTK1, PRO0412, RP3-473J16.4

Background: Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli including growth factors. The MEK kinases (also designated MAP kinase kinase kinases, MKKKs, MAP3Ks or MEKKs) phosphorylate and thereby activate the MEKs (also called MAP kinase kinases or MKKs), including ERK, JNK and p38. These activated MEKs in turn phosphorylate and activate the MAP kinases. The MEK kinases include Raf-1, Raf-B, Mos, MEK kinase-1, MEK kinase-2, MEK kinase-3, MEK kinase-4, ASK 1 (MEK kinase-5) and MAP3K6 (MEK kinase-6). MEK kinase-1 has been shown to phosphorylate MEK-1 via Raf-independent pathway. Evidence suggests that MEK-3 is preferentially activated by MEK kinase-3 and that MEK-4 is activated by both MEK kinase-2 and MEK kinase-3. MEK kinase-4 has been shown to specifically activate the JNK path-way. ASK1 activates both MEK-4 and MEK-3/MEK-6 pathways.

Pathways: MAPK Signalweg