NOTUM Antikörper (AA 351-450) (Biotin)

Produktnummer ABIN1394017

Produktdetails anti-NOTUM Antikörper (Biotin)

Target: NOTUM (Notum Pectinacetylesterase Homolog (NOTUM))

Bindungsspezifität: AA 351-450

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NOTUM Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Cow,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NOTUM

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu NOTUM

Target: NOTUM (Notum Pectinacetylesterase Homolog (NOTUM))

Andere Bezeichnung: NOTUM (NOTUM Produkte)

Synonyme: 5730593N15Rik antikoerper, RGD1307119 antikoerper, notum, palmitoleoyl-protein carboxylesterase antikoerper, notum pectinacetylesterase homolog (Drosophila) antikoerper, NOTUM, palmitoleoyl-protein carboxylesterase antikoerper, NOTUM antikoerper, Notum antikoerper

Hintergrund:

Synonyms: NOTUM, notum pectinacetylesterase homolog Drosophila, Notum pectinacetylesterase homolog, NOTUM_HUMAN.

Background: Notum is a 496 amino acid secreted protein that belongs to the pectinacetylesterase family and may deacetylate GlcNAc residues on cell surface glycans. The gene that encodes Notum consists of approximately 9,334 bases and maps to human chromosome 17q25.3. Encoding more than 1,200 genes, chromosome 17 comprises over 2.5 % of the human genome. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of ovary, colon, prostate gland and fallopian tubes.

Gen-ID: 147111

UniProt: Q6P988