PHYHIP Antikörper (AA 231-330) (AbBy Fluor® 488)

Produktnummer ABIN1394134

Produktdetails anti-PHYHIP Antikörper (AbBy Fluor® 488)

Target: PHYHIP (Phytanoyl-CoA 2-Hydroxylase Interacting Protein (PHYHIP))

Bindungsspezifität: AA 231-330

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PHYHIP Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PHYHIP

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu PHYHIP

Target: PHYHIP (Phytanoyl-CoA 2-Hydroxylase Interacting Protein (PHYHIP))

Andere Bezeichnung: PHYHIP (PHYHIP Produkte)

Synonyme: PHYHIP antikoerper, DYRK1AP3 antikoerper, PAHX-AP antikoerper, PAHXAP1 antikoerper, AW049870 antikoerper, C630010D02Rik antikoerper, Lnap1ip antikoerper, PAHX-AP1 antikoerper, phytanoyl-CoA 2-hydroxylase interacting protein antikoerper, phytanoyl-CoA hydroxylase interacting protein antikoerper, PHYHIP antikoerper, phyhip antikoerper, Phyhip antikoerper

Hintergrund:

Synonyms: DYRK1A interacting protein 3, DYRK1AP3, PAHX AP1, PAHXAP1, phytanoyl CoA 2 hydroxylase interacting protein, phytanoyl CoA alpha hydroxylase associated protein, Phytanoyl CoA hydroxylase associated protein 1, Phytanoyl CoA hydroxylase interacting protein, Similar to a putative C.elegans gene encoded in cosmid M01B2, PHYIP_HUMAN.

Background: PHYHIP (Phytanoyl-CoA hydroxylase-interacting protein) is a 330 amino acid protein that is strongly expressed in brain, with weak expression in ovary, small intestine and ovary. In transgenic mice, overexpression of PHYHIP in heart results in tachycardia and tachyarrhythmia. PHYHIP interacts with the Refsum disease gene product, PAHX, indicating that PHYHIP may play a role in the CNS deficits of Refsum disease, which is characterized by cerebellar degeneration, neurologic damage and peripheral neuropathies. PHYHIP also interacts with Dyrk1A, a protein that that is overexpressed in brain of Down-syndrome patients, therefore PHYHIP may participate in some of the neurological abnormalities of Down syndrome. Significantly, the gene encoding PHYHIP is localized to a region of the short arm of human chromosome 8 that is frequently found deleted in prostate, breast and several other types of cancers.