Fibrillin 2 Antikörper (AA 1001-1200) (AbBy Fluor® 647)

Produktnummer ABIN1395540

Produktdetails anti-Fibrillin 2 Antikörper (AbBy Fluor® 647)

Target: Fibrillin 2 (FBN2)

Bindungsspezifität: AA 1001-1200

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Fibrillin 2 Antikörper ist konjugiert mit AbBy Fluor® 647

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Fibrillin 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Fibrillin 2

Target: Fibrillin 2 (FBN2)

Andere Bezeichnung: Fibrillin 2 (FBN2 Produkte)

Synonyme: CCA antikoerper, DA9 antikoerper, BC063774 antikoerper, Fib-2 antikoerper, mKIAA4226 antikoerper, sne antikoerper, sy antikoerper, FBN2 antikoerper, fibrillin 2 antikoerper, fibrillin 3 antikoerper, FBN2 antikoerper, Fbn2 antikoerper, FBN3 antikoerper

Hintergrund:

Synonyms: CCA, congenital contractural arachnodactyly Marfanoid-like, DA9, FBN2, FBN2_HUMAN, fibrillin 2 congenital contractural arachnodactyly, Fibrillin-2.

Background: Extracellular glycoproteins fibrillin-1 and -2 are major components of connective tissue microfibrils. Fibrillin-2 containing microfibrils regulate the early process of elastic fiber assembly in tissue. Mutations in the fibrillin-2 gene resulting in impaired assembly of fibrillin-2 may lead to molecular congenital contractural arachnodactyly. Fibrillin-2 constitutes the backbone of microfibrils which insert directly into the lamina densa of basement membranes. Epithelial cells primarily deposit fibrillin into the extracellular matrix in a nonfibrillar form. Mutations in the 8-cysteine motif of Fibrillin-2 alters its binding to microfibril-associated glycoprotein-1 (MAGP-1), which may increase the severity of congenital contractural arachnodactyly.

Pathways: Maintenance of Protein Location, SARS-CoV-2 Protein Interaktom