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MLC1 Antikörper (AA 321-377) (AbBy Fluor® 555)

Reaktivität: Maus, Ratte WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 555
Produktnummer ABIN1397900
  • Target Alle MLC1 Produkte
    MLC1
    Bindungsspezifität
    • 14
    • 14
    • 8
    • 5
    • 1
    • 1
    • 1
    • 1
    AA 321-377
    Reaktivität
    • 23
    • 15
    • 15
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Maus, Ratte
    Wirt
    • 37
    • 1
    Kaninchen
    Klonalität
    • 38
    Polyklonal
    Konjugat
    • 11
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MLC1 Antikörper ist konjugiert mit AbBy Fluor® 555
    Applikation
    • 32
    • 20
    • 12
    • 12
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Maus, Ratte
    Homologie
    Human,Dog,Pig,Horse,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human MLC1
    Isotyp
    IgG
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    MLC1
    Abstract
    MLC1 Produkte
    Synonyme
    LVM antikoerper, MLC antikoerper, VL antikoerper, AW048630 antikoerper, BB074274 antikoerper, Kiaa0027-hp antikoerper, WKL1 antikoerper, mKIAA0027 antikoerper, si:ch211-192n14.1 antikoerper, megalencephalic leukoencephalopathy with subcortical cysts 1 antikoerper, megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human) antikoerper, MLC1 antikoerper, Mlc1 antikoerper, mlc1 antikoerper
    Hintergrund

    Synonyms: KIAA0027, LVM, Megalencephalic leukoencephalopathy with subcortical cysts 1, Membrane protein MLC1, MLC, MLC-1, MLC1_HUMAN, VL, WKL1.

    Background: MLC1 is a 377 amino acid multi-pass membrane protein that may serve as a non-selective neuronal cation channel in brain. Mutant MLC1 proteins that show impaired folding have been corrected in vitro with the addition of a Ca(2+)-ATPase inhibitor, curcumin. Mutations in the gene encoding MLC1 is the cause of megalencephalic leukoencephalopathy with subcortical cysts, also known as van der Knaap disease, a rare syndrome characterized early in life by progressive brain destruction causing mental retardation and incoordination. Single nucleotide polymorphisms within the MLC1 gene may be associated with periodic catatonia, but there seems to be conflicting evidence on whether or not the gene is implicated in general schizophrenia.

    Gen-ID
    23209
    UniProt
    Q15049
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