PANK2 Antikörper (AA 401-500) (AbBy Fluor® 488)

Produktnummer ABIN1398502

Produktdetails anti-PANK2 Antikörper (AbBy Fluor® 488)

Target: PANK2 (Pantothenate Kinase 2 (PANK2))

Bindungsspezifität: AA 401-500

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PANK2 Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Cow,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PANK2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu PANK2

Target: PANK2 (Pantothenate Kinase 2 (PANK2))

Andere Bezeichnung: PANK2 (PANK2 Produkte)

Synonyme: ATPANK2 antikoerper, F10M6.180 antikoerper, F10M6_180 antikoerper, pantothenate kinase 2 antikoerper, PANK2 antikoerper, C20orf48 antikoerper, HARP antikoerper, HSS antikoerper, NBIA1 antikoerper, PKAN antikoerper, 4933409I19Rik antikoerper, AI642621 antikoerper, pantothenate kinase 2 antikoerper, pantothenate kinase 2, mitochondrial antikoerper, ribonuclease A family member 11 (inactive) antikoerper, PANK2 antikoerper, Tsp_01576 antikoerper, LOC100539295 antikoerper, Pank2 antikoerper, RNASE11 antikoerper

Hintergrund:

Synonyms: Pantothenate kinase 2, mitochondrial, hPanK2, Pantothenic acid kinase 2, PANK2, C20orf48, PANK2_HUMAN

Background: Defects in PANK2 are the cause of neurodegeneration with brain iron accumulation type 1 (NBIA1), also known as pantothenate kinase-associated neurodegeneration (PKAN) or Hallervorden-Spatz syndrome (HSS). It is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. Clinical manifestations include progressive muscle spasticity, hyperreflexia, muscle rigidity, dystonia, dysarthria, and intellectual deterioration which progresses to severe dementia over several years. It is clinically classified into classic, atypical, and intermediate phenotypes. Classic forms present with onset in the first decade, rapid progression, loss of independent ambulation within 15 years. Atypical forms have onset in the second decade, slow progression, maintenance of independent ambulation up to 40 years later. Intermediate forms manifest onset in the first decade with slow progression or onset in the second decade with rapid progression. Patients with early onset tend to also develop pigmentary retinopathy, whereas those with later onset tend to also have speech disorders and psychiatric features. All patients have the 'eye of the tiger' sign on brain MRI.Defects in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP). HARP is a rare syndrome with many clinical similarities to NBIA1.

Gen-ID: 80025

UniProt: Q9BZ23

Pathways: Ribonucleoside Biosynthetic Process