RBX1 Antikörper (AA 1-70) (Biotin)

Produktnummer ABIN1398817

Produktdetails anti-RBX1 Antikörper (Biotin)

Target: RBX1 (Ring-Box 1, E3 Ubiquitin Protein Ligase (RBX1))

Bindungsspezifität: AA 1-70

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RBX1 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Cow

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ROC1/RNF75

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu RBX1

Target: RBX1 (Ring-Box 1, E3 Ubiquitin Protein Ligase (RBX1))

Andere Bezeichnung: RNF75 (RBX1 Produkte)

Synonyme: BA554C12.1 antikoerper, RNF75 antikoerper, ROC1 antikoerper, 1500002P15Rik antikoerper, AA517855 antikoerper, im:7137515 antikoerper, zgc:136444 antikoerper, RBX1 antikoerper, ATRBX1 antikoerper, F7C8.160 antikoerper, F7C8_160 antikoerper, HRT1 antikoerper, REGULATOR OF CULLINS-1 antikoerper, RING-BOX 1 antikoerper, RING-box 1 antikoerper, hop21 antikoerper, BEST:CK01110 antikoerper, CG16982 antikoerper, CK01110 antikoerper, Dmel\CG16982 antikoerper, EG:115C2.11 antikoerper, Rbx1 antikoerper, Rbx1/Roc antikoerper, Roc antikoerper, Roc1alpha antikoerper, anon-EST:Posey65 antikoerper, dRbx1 antikoerper, dRoc1 antikoerper, dRoc1a antikoerper, ring-box 1 antikoerper, ring-box 1, E3 ubiquitin protein ligase antikoerper, RING-box 1 antikoerper, RING-box protein 1 antikoerper, RING-box protein 1a antikoerper, Regulator of cullins 1a antikoerper, RBX1 antikoerper, Rbx1 antikoerper, rbx1 antikoerper, MGG_08844 antikoerper, LOC9308017 antikoerper, rbx-1 antikoerper, Roc1a antikoerper

Hintergrund:

Synonyms: E3 ubiquitin-protein ligase RBX1, MGC13357, MGC1481, Protein ZYP, Rbx 1, Rbx1, RBX1_HUMAN, Regulator of Cullins 1, Ring box 1, RING box protein 1, RING finger protein 75, RING finger protein, RING-box protein 1, Ringbox protein 1, RNF 75, RNF75, ROC 1, ZYP protein.

Background: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M.

Gen-ID: 9978

Pathways: Zellzyklus, M Phase, SARS-CoV-2 Protein Interaktom