FBXO11 Antikörper (AA 65-160) (Biotin)
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- Target Alle FBXO11 Antikörper anzeigen
- FBXO11 (F-Box Protein 11 (FBXO11))
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Bindungsspezifität
- AA 65-160
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser FBXO11 Antikörper ist konjugiert mit Biotin
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Applikation
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Homologie
- Human,Mouse,Rat,Cow,Sheep,Pig,Horse,Chicken
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human FBXO11
- Isotyp
- IgG
- Top Product
- Discover our top product FBXO11 Primärantikörper
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anti-F-Box Protein 11 (FBXO11) (AA 744-843) antibody
FBXO11 Reaktivität: Human WB, ELISA, IF, IHC (p) Wirt: Maus Monoclonal 4C12 unconjugated
anti-F-Box Protein 11 (FBXO11) (AA 65-160) antibodyFBXO11 Reaktivität: Human ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-F-Box Protein 11 (FBXO11) antibodyFBXO11 Reaktivität: Human, Maus WB, IF Wirt: Kaninchen Polyclonal unconjugated
anti-F-Box Protein 11 (FBXO11) (AA 1-843) antibodyFBXO11 Reaktivität: Human WB, IF Wirt: Maus Polyclonal unconjugated
anti-F-Box Protein 11 (FBXO11) (AA 744-844) antibodyFBXO11 Reaktivität: Human WB, ELISA, IF, IHC, IHC (p) Wirt: Maus Monoclonal 4C12 unconjugated
anti-F-Box Protein 11 (FBXO11) (Internal Region) antibodyFBXO11 Reaktivität: Human, Maus, Ratte WB, ELISA, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-F-Box Protein 11 (FBXO11) (Middle Region) antibodyFBXO11 Reaktivität: Human, Maus, Ratte, Pferd, Zebrafisch (Danio rerio), Hund, Meerschweinchen, Kaninchen WB, ChIP Wirt: Kaninchen Polyclonal unconjugated
anti-F-Box Protein 11 (FBXO11) (AA 181-453) antibodyFBXO11 Reaktivität: Human ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-F-Box Protein 11 (FBXO11) (AA 688-927) antibodyFBXO11 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-F-Box Protein 11 (FBXO11) (AA 1-170) antibodyFBXO11 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
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IHC-P 1:200-400
IHC-F 1:100-500 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C for 12 months.
- Haltbarkeit
- 12 months
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- Target
- FBXO11 (F-Box Protein 11 (FBXO11))
- Andere Bezeichnung
- FBXO11 (FBXO11 Produkte)
- Hintergrund
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Synonyms: UBR6, VIT1, FBX11, PRMT9, UG063H01, F-box only protein 11, Protein arginine N-methyltransferase 9, Vitiligo-associated protein 1, VIT-1, FBXO11
Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
- Gen-ID
- 80204
- UniProt
- Q86XK2
- Pathways
- Sensory Perception of Sound
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