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KRIT1 Antikörper (AA 631-736) (Biotin)

KRIT1 Reaktivität: Maus WB, ELISA, IHC (fro), IHC (p) Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN1399645
  • Target Alle KRIT1 Antikörper anzeigen
    KRIT1 (KRIT1, Ankyrin Repeat Containing (KRIT1))
    Bindungsspezifität
    • 14
    • 7
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 631-736
    Reaktivität
    • 29
    • 19
    • 5
    Maus
    Wirt
    • 39
    • 4
    Kaninchen
    Klonalität
    • 40
    • 3
    Polyklonal
    Konjugat
    • 16
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser KRIT1 Antikörper ist konjugiert mit Biotin
    Applikation
    • 36
    • 21
    • 13
    • 13
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Kreuzreaktivität
    Maus
    Homologie
    Human,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human KRIT1
    Isotyp
    IgG
    Top Product
    Discover our top product KRIT1 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    KRIT1 (KRIT1, Ankyrin Repeat Containing (KRIT1))
    Andere Bezeichnung
    KRIT1 (KRIT1 Produkte)
    Synonyme
    CAM antikoerper, CCM1 antikoerper, 2010007K12Rik antikoerper, A630036P20Rik antikoerper, AA432855 antikoerper, AI450393 antikoerper, AI643869 antikoerper, BB155247 antikoerper, BB235701 antikoerper, Ccm1 antikoerper, RGD1305929 antikoerper, krit1 antikoerper, fb36f07 antikoerper, san antikoerper, santa antikoerper, wu:fb36f07 antikoerper, zgc:63585 antikoerper, KRIT1, ankyrin repeat containing antikoerper, KRIT1 antikoerper, Krit1 antikoerper, krit1 antikoerper
    Hintergrund

    Synonyms: CAM, CCM1, Krev interaction trapped protein 1, Krev interaction trapped 1, Cerebral cavernous malformations 1 protein, KRIT1

    Background: Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1, this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.

    Gen-ID
    889
    UniProt
    O00522
    Pathways
    Cell RedoxHomeostasis
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