HOXD9 Antikörper (AA 251-352) (AbBy Fluor® 350)

Produktnummer ABIN1399971

Produktdetails anti-HOXD9 Antikörper (AbBy Fluor® 350)

Target: HOXD9 (Homeobox D9 (HOXD9))

Bindungsspezifität: AA 251-352

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HOXD9 Antikörper ist konjugiert mit AbBy Fluor® 350

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HOXD9

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu HOXD9

Target: HOXD9 (Homeobox D9 (HOXD9))

Andere Bezeichnung: HOXD9 (HOXD9 Produkte)

Synonyme: Hox-4.4 antikoerper, Hox-5.2 antikoerper, Xhoxd9 antikoerper, HOX4 antikoerper, HOX4C antikoerper, Hox-4.3 antikoerper, hoxd9 antikoerper, z-28 antikoerper, hoxd9a antikoerper, homeobox D9 antikoerper, homeobox D9 S homeolog antikoerper, homeo box D9 antikoerper, homeobox D9a antikoerper, Hoxd9 antikoerper, HOXD9 antikoerper, hoxd9.S antikoerper, hoxd9a antikoerper, hoxd9 antikoerper

Hintergrund:

Synonyms: homeobox D9, Homeobox protein Hox D9, Hox 4.3, Hox 5.2, HOX4, HOX4C, RP23 313J15.10, HXD9_HUMAN.

Background: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. In vivo, the HoxD9 protein interacts with the autoregulatory and cross-regulatory enhancers of the murine HoxB1 and human HoxD9 genes. Specifically, the HoxD9 protein interacts with the human control region (HCR) of the HoxD9 gene, thus inducing transcription of the HoxD9 promoter. HoxD9 may be a multifunctional transcriptional regulator, as it contains different activation domains. Activation of HoxD9 depends on the structure of the target regulatory element, and results in differential cofactor interaction. The HoxD9 protein is expressed in the early stages of mouse joint development, primarily in the articular cartilage. HoxD9 transcripts are also detected in the synovial tissue of arthritic mice, but not in that of normal mice, suggesting that HoxD9 may have a role in the pathology of arthritis. Furthermore, the HoxD9 protein is highly expressed in the synoviocytes of patients with rheumatoid arthritis (RA), but not in osteoarthritis patients. The human HoxD9 protein is also differentially expressed in the human cervical cancer cell line HeLa, but is not expressed in the normal cervix and may thus play a role in tumorigenesis.