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DIS3L Antikörper (AbBy Fluor® 350)

DIS3L Reaktivität: Human, Maus, Ratte WB, IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 350
Produktnummer ABIN1400553
  • Target Alle DIS3L Antikörper anzeigen
    DIS3L (DIS3-Like Exonuclease 1 (DIS3L))
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 34
    • 3
    Kaninchen
    Klonalität
    • 37
    Polyklonal
    Konjugat
    • 10
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DIS3L Antikörper ist konjugiert mit AbBy Fluor® 350
    Applikation
    • 32
    • 17
    • 14
    • 12
    • 5
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human DIS3L
    Isotyp
    IgG
    Top Product
    Discover our top product DIS3L Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    DIS3L (DIS3-Like Exonuclease 1 (DIS3L))
    Andere Bezeichnung
    DIS3L (DIS3L Produkte)
    Synonyme
    DIS3L1 antikoerper, AV340375 antikoerper, RGD1308959 antikoerper, zgc:158615 antikoerper, DIS3 like exosome 3'-5' exoribonuclease antikoerper, DIS3-like exosome 3'-5' exoribonuclease antikoerper, DIS3L antikoerper, dis3l antikoerper, Dis3l antikoerper, dis3l.L antikoerper
    Hintergrund

    Synonyms: DIS3 like exonuclease 1, DIS3 mitotic control homolog S. cerevisiae like, FLJ38088, KIAA1955, MGC4562, DI3L1_HUMAN.

    Background: The exosome is a multi-protein complex composed of several highly conserved subunits, some of which are 3? to 5? exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich elements (AREs) in their untranslated 3? regions. DIS3, also known as RRP44, is a 958 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one PINc domain. Widely expressed with highest expression in testis, DIS3 functions as a component of the exosome exoribonuclease complex and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis. Multiple isoforms of DIS3 exist due to alternative splicing events.

    Gen-ID
    115752
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