AGXT2L2 Antikörper (AbBy Fluor® 647)

Produktnummer ABIN1400808

Produktdetails anti-AGXT2L2 Antikörper (AbBy Fluor® 647)

Target: AGXT2L2 (Alanine-Glyoxylate Aminotransferase 2-Like 2 (AGXT2L2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AGXT2L2 Antikörper ist konjugiert mit AbBy Fluor® 647

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AGXT2L2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu AGXT2L2

Target: AGXT2L2 (Alanine-Glyoxylate Aminotransferase 2-Like 2 (AGXT2L2))

Andere Bezeichnung: AGXT2L2 (AGXT2L2 Produkte)

Synonyme: AGXT2L2 antikoerper, PHLU antikoerper, Agxt2l2 antikoerper, 2900006B13Rik antikoerper, 5-phosphohydroxy-L-lysine phospho-lyase antikoerper, 5-phosphohydroxy-L-lysine phospholyase antikoerper, PHYKPL antikoerper, phykpl antikoerper, Phykpl antikoerper

Hintergrund:

Synonyms: Alanine glyoxylate aminotransferase 2 like 2, MGC117348, AT2L2_HUMAN.

Background: Members of the class-III pyridoxal-phosphate-dependent aminotransferase family, such as AGXT2, catalyze the conversion of glyoxylate to glycine using L-alanine as the amino donor. AGXT2 protects from asymmetric dimethylarginine (ADMA)-induced inhibition in nitric oxide (NO) production. Elevated blood concentrations of ADMA, a methyl derivate of the amino acid arginine and an endogenous inhibitor of nitric oxide (NO) synthase, is produced by the physiological degradation of methylated proteins and is found in association with diabetes, hypertension, congestive heart failure and atherosclerosis. AGXT2L2 (alanine-glyoxylate aminotransferase 2-like 2) is a 450 amino acid pyridoxal phosphate that exists as a homotetramer. Belonging to the class-III pyridoxal-phosphate-dependent aminotransferase family, AGXT2L2 localizes to the mitochondria and exists as three alternatively spliced isoforms. Encoded by a gene located on human chromosome 5q35.3, AGXT2L2 may have similar functions as AGXT2.