ZNRF2 Antikörper (AbBy Fluor® 350)

Produktnummer ABIN1401063

Produktdetails anti-ZNRF2 Antikörper (AbBy Fluor® 350)

Target: ZNRF2 (Zinc and Ring Finger 2 (ZNRF2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZNRF2 Antikörper ist konjugiert mit AbBy Fluor® 350

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ZNRF2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu ZNRF2

Target: ZNRF2 (Zinc and Ring Finger 2 (ZNRF2))

Andere Bezeichnung: ZNRF2 (ZNRF2 Produkte)

Synonyme: RNF202 antikoerper, 1190002C14Rik antikoerper, AU044205 antikoerper, D6Ertd365e antikoerper, zgc:152865 antikoerper, znrf2 antikoerper, Znrf1 antikoerper, zgc:171663 antikoerper, zinc and ring finger 2 antikoerper, zinc and ring finger 2b antikoerper, zinc and ring finger 2a antikoerper, ZNRF2 antikoerper, Znrf2 antikoerper, znrf2b antikoerper, znrf2a antikoerper

Hintergrund:

Synonyms: E3 ubiquitin-protein ligase ZNRF2, Protein Ells2, RING finger protein 202, Zinc/RING finger protein 2, Znrf2, ZNRF2_HUMAN.

Background: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). ZNRF2 (zinc and ring finger 2), also known as RNF202, is a 242 amino acid peripheral membrane protein that contains one RING-type zinc finger and localizes to the lysosome, as well as the endosome and the cell junction. Expressed at high levels in brain tissue, ZNRF2 is thought to function as an E3 ubiquitin-protein ligase that may be involved in the establishment and maintenance of neuronal transmission and plasticity. Upon DNA damage, ZNRF2 is subject to phosphorylation, probably by ATR or ATM.

Gen-ID: 223082

Pathways: Synaptic Membrane