SH3RF1 Antikörper (AbBy Fluor® 647)

Produktnummer ABIN1401156

Produktdetails anti-SH3RF1 Antikörper (AbBy Fluor® 647)

Target: SH3RF1 (SH3 Domain Containing Ring Finger 1 (SH3RF1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SH3RF1 Antikörper ist konjugiert mit AbBy Fluor® 647

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SH3MD2/RNF142

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu SH3RF1

Target: SH3RF1 (SH3 Domain Containing Ring Finger 1 (SH3RF1))

Andere Bezeichnung: RNF142 (SH3RF1 Produkte)

Synonyme: SH3MD2 antikoerper, posh antikoerper, xPOSH antikoerper, rnf142 antikoerper, sh3md2 antikoerper, MGC135632 antikoerper, MGC189605 antikoerper, POSH antikoerper, RNF142 antikoerper, 2200003J05Rik antikoerper, Posh antikoerper, R75531 antikoerper, Sh3md2 antikoerper, si:ch211-114c9.2 antikoerper, si:dkey-15j16.4 antikoerper, wu:fi42f11 antikoerper, SH3 domain containing ring finger 1 antikoerper, SH3 domain containing ring finger 1 S homeolog antikoerper, SH3RF1 antikoerper, sh3rf1 antikoerper, sh3rf1.S antikoerper, Sh3rf1 antikoerper

Hintergrund:

Synonyms: Plenty of SH3 domains, Plenty of SH3s, POSH, Ring finger protein 142, RNF 142, RNF142, SH3 domain containing ring finger 1, SH3 domain containing RING finger protein 1, SH3MD2, SH3 multiple domains 2, SH3RF1.

Background: SH3MD2 acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9). SH3MD2 may be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane. This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. There are two named isoforms.

Gen-ID: 57630