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PDZRN3 Antikörper (AbBy Fluor® 647)

PDZRN3 Reaktivität: Human, Maus, Ratte WB, IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 647
Produktnummer ABIN1401366
  • Target Alle PDZRN3 Antikörper anzeigen
    PDZRN3 (PDZ Domain Containing Ring Finger 3 (PDZRN3))
    Reaktivität
    • 25
    • 18
    • 16
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 24
    • 1
    Kaninchen
    Klonalität
    • 25
    Polyklonal
    Konjugat
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PDZRN3 Antikörper ist konjugiert mit AbBy Fluor® 647
    Applikation
    • 21
    • 12
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human SEMCAP3/LNX3
    Isotyp
    IgG
    Top Product
    Discover our top product PDZRN3 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    PDZRN3 (PDZ Domain Containing Ring Finger 3 (PDZRN3))
    Andere Bezeichnung
    SEMCAP3 (PDZRN3 Produkte)
    Synonyme
    MGC80196 antikoerper, pdzrn3 antikoerper, LNX3 antikoerper, SEMACAP3 antikoerper, 1110020C07Rik antikoerper, AI429718 antikoerper, AL023082 antikoerper, Semcap3 antikoerper, PDZ domain containing ring finger 3 antikoerper, PDZ domain containing ring finger 3 L homeolog antikoerper, PDZ domain containing RING finger 3b antikoerper, E3 ubiquitin-protein ligase PDZRN3 antikoerper, PDZ domain containing RING finger 3 antikoerper, PDZRN3 antikoerper, pdzrn3.L antikoerper, pdzrn3b antikoerper, LOC100228989 antikoerper, pdzrn3 antikoerper, Pdzrn3 antikoerper
    Hintergrund

    Synonyms: Ligand of Numb protein X 3, likely ortholog of mouse semaF cytoplasmic domain associated protein 3, LNX3, PDZ domain containing ring finger 3, Protein SEMACAP3, SEMACAP3, Semaphorin cytoplasmic domain associated protein, PZRN3_HUMAN.

    Background: PDZRN3 contains a RING-finger motif in its N-terminal region, two PDZ domains in its central region and a consensus-binding motif for PDZ domains at its C-terminus. It was identified in silico as a homolog of the protein known as LNX1 or SEMCAP1, which possesses ubiquitin ligase activity and binds the membrane protein Semaphorin 4C. However, PDZRN3 itself has not previously been characterized. We have now evaluated the properties and functions of PDZRN3. The PDZRN3 gene was shown to be expressed in various human tissues including the heart, skeletal muscle and liver and its expression in mouse skeletal muscle was developmentally regulated. Both the differentiation of C2C12 mouse skeletal myoblasts into myotubes and injury-induced muscle regeneration in vivo were found to be accompanied by up-regulation of PDZRN3. The differentiation-associated increase in the expression of PDZRN3 in C2C12 cells follows that of myogenin and precedes that of myosin heavy chain. Depletion of PDZRN3 by RNA interference inhibited the formation of myotubes as well as the associated up-regulation of myosin heavy chain in C2C12 cells. Our data suggest that PDZRN3 plays an essential role in the differentiation of myoblasts into myotubes by acting either downstream or independently of myogenin.

    Gen-ID
    23024
    Pathways
    Skeletal Muscle Fiber Development
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