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SASS6 Antikörper (AbBy Fluor® 555)

SASS6 Reaktivität: Human, Maus, Ratte WB, IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 555
Produktnummer ABIN1401929
  • Target Alle SASS6 Antikörper anzeigen
    SASS6 (Spindle Assembly 6 Homolog (SASS6))
    Reaktivität
    • 37
    • 17
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    Human, Maus, Ratte
    Wirt
    • 35
    • 2
    Kaninchen
    Klonalität
    • 37
    Polyklonal
    Konjugat
    • 14
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SASS6 Antikörper ist konjugiert mit AbBy Fluor® 555
    Applikation
    • 34
    • 14
    • 12
    • 4
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human SASS6
    Isotyp
    IgG
    Top Product
    Discover our top product SASS6 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    SASS6 (Spindle Assembly 6 Homolog (SASS6))
    Andere Bezeichnung
    SASS6 (SASS6 Produkte)
    Synonyme
    SAS-6 antikoerper, SAS6 antikoerper, 2810453L12Rik antikoerper, RGD1306255 antikoerper, CG15524 antikoerper, DSAS-6 antikoerper, DSas-6 antikoerper, DSas6 antikoerper, Dmel\\CG15524 antikoerper, Dsas6 antikoerper, Sas-6 antikoerper, Sas6 antikoerper, dsas-6 antikoerper, sas6 antikoerper, wu:fb98c12 antikoerper, zgc:55668 antikoerper, SASS6 antikoerper, sass6.2 antikoerper, SAS-6 centriolar assembly protein antikoerper, Spindle assembly abnormal 6 antikoerper, spindle assembly 6 homolog L homeolog antikoerper, SAS-6 centriolar assembly protein L homeolog antikoerper, SASS6 antikoerper, Sass6 antikoerper, Sas-6 antikoerper, sass6.L antikoerper, sass6 antikoerper, sass6.2.L antikoerper
    Hintergrund

    Synonyms: HsSAS 6, HsSAS6, MGC119440, SAS 6, SAS6, SASS 6, Spindle assembly 6 homolog C. elegans, Spindle assembly 6 homolog, Spindle assembly abnormal protein 6 homolog, PJA2_HUMAN.

    Background: SAS-6 (spindle assembly abnormal protein 6 homolog, HsSAS-6) is a 657 amino acid protein encoded by the human gene SAS6. SAS-6 is a component of the centrosome that contains one PISA (present in SAS-6) domain. LK4, SAS-6, CPAP and other centriole related proteins are required at different stages of procentriole formation and were associated with different centriolar structures. SAS-6 associates only transiently with nascent procentrioles, whereas CEP135 and CPAP form a core structure within the proximal lumen of both parental and nascent centrioles. SAS-6 is necessary for procentriole formation in human cell lines and is localized asymmetrically next to the centriole at the onset of procentriole formation. SAS-6 levels oscillate during the cell cycle, it is degraded in mitosis starting at anaphase, and it accumulates again at the end of the following G1 phase. The anaphase-promoting complex targets SAS-6 for degradation by the 26S Proteasome, and a KEN box in the C-terminus of SAS-6 is necessary for its degradation. Increased SAS-6 levels promoted the formation of multiple procentrioles forming next to a single centriole.

    Gen-ID
    163786
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