SHARPIN Antikörper (AA 260-310) (AbBy Fluor® 350)
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- Target Alle SHARPIN Antikörper anzeigen
- SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))
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Bindungsspezifität
- AA 260-310
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Reaktivität
- Human, Ratte, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SHARPIN Antikörper ist konjugiert mit AbBy Fluor® 350
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Applikation
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Human, Maus, Ratte
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human SHARPIN
- Isotyp
- IgG
- Top Product
- Discover our top product SHARPIN Primärantikörper
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- Applikationshinweise
- IF(IHC-P) 1:50-200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))
- Andere Bezeichnung
- SHARPIN (SHARPIN Produkte)
- Synonyme
- 0610041B22Rik antikoerper, AW121341 antikoerper, RBCKL1 antikoerper, SIPL1 antikoerper, cpdm antikoerper, Conneck1 antikoerper, SHANK-associated RH domain interacting protein antikoerper, SHANK associated RH domain interactor antikoerper, SHANK-associated RH domain interactor antikoerper, Sharpin antikoerper, SHARPIN antikoerper
- Hintergrund
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Synonyms: SIPL1, Sharpin, Shank-associated RH domain-interacting protein, Shank-interacting protein-like 1, hSIPL1, PSEC0216
Background: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.
- Gen-ID
- 81858
- UniProt
- Q9H0F6
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