MIS18 Binding Protein 1 (MIS18BP1) Antikörper (AbBy Fluor® 647)

Produktnummer ABIN1403664

Produktdetails

Target: MIS18 Binding Protein 1 (MIS18BP1)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: AbBy Fluor® 647

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KNL2/C14orf106

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: MIS18 Binding Protein 1 (MIS18BP1)

Andere Bezeichnung: C14orf106 (MIS18BP1 Produkte)

Synonyme: C14orf106 antikoerper, HSA242977 antikoerper, KNL2 antikoerper, M18BP1 antikoerper, 6720403H11 antikoerper, C79407 antikoerper, Knl2 antikoerper, mKIAA1903 antikoerper, MIS18 binding protein 1 antikoerper, MIS18BP1 antikoerper, Mis18bp1 antikoerper

Hintergrund:

Synonyms: Chromosome 14 open reading frame 106, HsKNL-2, KIAA1903, Kinetochore-associated protein KNL-2 homolog, M18BP1, Mis18-binding protein 1, MIS18BP1, P243, Putative protein p243 which interacts with transcription factor Sp1, Uncharacterized potential DNA binding protein C14orf106, M18BP_HUMAN.

Background: C14orf106 is required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. It interacts with SP1. There are two isoforms.Chromosome 14 contains about 700 genes and 106 million base pairs and makes up about 3.5 % of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and when defective leads to the genetic disorder ?-antitrypsin deficiency. This disorder is characterized by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus is found on chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein BCL3 in the (14,19) translocations found in a variety of B cell malignancies. The C14orf106 gene product has been provisionally designated C14orf106 pending further characterization.

Pathways: Chromatin Binding