C14orf174 Antikörper (Biotin)

Produktnummer ABIN1403677

Produktdetails anti-C14orf174 Antikörper (Biotin)

Target: C14orf174 (Chromosome 14 Open Reading Frame 174 (C14orf174))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C14orf174 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SAMD15/C14orf174

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu C14orf174

Target: C14orf174 (Chromosome 14 Open Reading Frame 174 (C14orf174))

Andere Bezeichnung: C14orf174 (C14orf174 Produkte)

Synonyme: C14orf174 antikoerper, FAM15A antikoerper, Gm263 antikoerper, sterile alpha motif domain containing 15 antikoerper, SAMD15 antikoerper, Samd15 antikoerper

Hintergrund:

Synonyms: chromosome 14 open reading frame 174, FAM15A, SAM domain-containing protein 15, SAM15_HUMAN, SAMD15, Sterile alpha mot domain-containing protein 15.

Background: C14orf174, is a 674 amino acid protein that contains one SAM (sterile alpha motif) domain. Existing as two alternatively spliced isoforms,C14orf174 is encoded by a gene that maps to human chromosome 14q24.3. Chromosome 14 contains about 700 genes and 106 million base pairs and makes up about 3.5 % of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and when defective leads to the genetic disorder ?-antitrypsin deficiency. This disorder is characterized by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus is found on chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein Bcl-3 in the (14,19) translocations found in a variety of B cell malignancies.