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PCGF2 Antikörper (AA 170-210) (Biotin)

PCGF2 Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN1404007
  • Target Alle PCGF2 Antikörper anzeigen
    PCGF2 (Polycomb Group Ring Finger 2 (PCGF2))
    Bindungsspezifität
    • 14
    • 8
    • 7
    • 7
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 170-210
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 37
    • 2
    • 1
    Kaninchen
    Klonalität
    • 38
    • 2
    Polyklonal
    Konjugat
    • 13
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PCGF2 Antikörper ist konjugiert mit Biotin
    Applikation
    • 35
    • 20
    • 13
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human MEL18
    Isotyp
    IgG
    Top Product
    Discover our top product PCGF2 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    IHC-P 1:200-400
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    PCGF2 (Polycomb Group Ring Finger 2 (PCGF2))
    Andere Bezeichnung
    MEL18 (PCGF2 Produkte)
    Synonyme
    ZNF144 antikoerper, PCGF2 antikoerper, MEL-18 antikoerper, RNF110 antikoerper, Mel18 antikoerper, Rnf110 antikoerper, Zfp144 antikoerper, mel-18 antikoerper, polycomb group ring finger 2 antikoerper, PCGF2 antikoerper, Pcgf2 antikoerper
    Hintergrund

    Synonyms: MEL-18, RNF110, ZNF144, Polycomb group RING finger protein 2, DNA-binding protein Mel-18, RING finger protein 110, Zinc finger protein 144, PCGF2, MEL18

    Background: Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1, unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex (By similarity).

    Gen-ID
    7703
    UniProt
    P35227
    Pathways
    Chromatin Binding
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