FEZ1 Antikörper (AbBy Fluor® 555)
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- Target Alle FEZ1 Antikörper anzeigen
- FEZ1 (Fasciculation and Elongation Protein zeta 1 (Zygin I) (FEZ1))
- Reaktivität
- Human, Ratte, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser FEZ1 Antikörper ist konjugiert mit AbBy Fluor® 555
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Applikation
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Human, Maus, Ratte
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human FEZ1
- Isotyp
- IgG
- Top Product
- Discover our top product FEZ1 Primärantikörper
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- Applikationshinweise
- IF(IHC-P) 1:50-200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- FEZ1 (Fasciculation and Elongation Protein zeta 1 (Zygin I) (FEZ1))
- Andere Bezeichnung
- FEZ1 (FEZ1 Produkte)
- Synonyme
- UNC-76 antikoerper, UNC76 antikoerper, wu:fj14c12 antikoerper, zgc:73258 antikoerper, fez1 antikoerper, xfez1 antikoerper, fasciculation and elongation protein zeta 1 antikoerper, fasciculation and elongation protein zeta 1 (zygin I) antikoerper, fasciculation and elongation protein zeta 1 L homeolog antikoerper, FEZ1 antikoerper, Fez1 antikoerper, fez1 antikoerper, fez1.L antikoerper
- Hintergrund
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Synonyms: Fasciculation and elongation protein zeta 1, Fasciculation and elongation protein zeta-1, Fez 1, Fez, Fez-like zinc finger protein, FEZ1, FEZ1_HUMAN, Fezl, Forebrain embryonic zinc-finger like protein, Zpf312, Zygin 1, Zygin I, Zygin-1, Zygin1, ZyginI.
Background: Frequent loss of heterozygosity (LOH) at human chromosome 8p22-p21 is associated with various tumors including prostate and breast cancer. The 8p22-p21 region contains the FEZ1 gene, which is altered in tumors of the esophagus, prostate and breast. The FEZ1 protein (also known as leucine zipper putative tumor suppressor or LZTS1) contains a DNA-binding leucine zipper motif. FEZ1 is expressed in normal breast and prostate, but alterations in FEZ1 expression result in abnormal cell growth. The absence of FEZ1 expression is characteristic of breast and prostate cancer cell lines as well as primary breast and pro-state tumors. This absence of FEZ1 may be due to several factors, including mutations in the FEZ1 gene or hypermethylation of the CpG island flanking the FEZ1 promoter region. FEZ1 acts as a negative regulator of cell growth. During cell-cycle progression, FEZ1 localizes to microtubule components and is hyperphosphorylated by cAMP-dependent kinase.
- Gen-ID
- 9638
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