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SH2D1A Antikörper (AbBy Fluor® 350)

SH2D1A Reaktivität: Human, Maus, Ratte WB, IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 350
Produktnummer ABIN1405161
  • Target Alle SH2D1A Antikörper anzeigen
    SH2D1A (SH2 Domain Containing 1A (SH2D1A))
    Reaktivität
    • 53
    • 24
    • 24
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 49
    • 3
    • 1
    • 1
    Kaninchen
    Klonalität
    • 53
    • 1
    Polyklonal
    Konjugat
    • 21
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SH2D1A Antikörper ist konjugiert mit AbBy Fluor® 350
    Applikation
    • 43
    • 19
    • 12
    • 4
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human SH2D1A/SAP
    Isotyp
    IgG
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    Discover our top product SH2D1A Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    SH2D1A (SH2 Domain Containing 1A (SH2D1A))
    Andere Bezeichnung
    SH2D1A (SH2D1A Produkte)
    Synonyme
    DSHP antikoerper, EBVS antikoerper, IMD5 antikoerper, LYP antikoerper, MTCP1 antikoerper, SAP antikoerper, SAP/SH2D1A antikoerper, XLP antikoerper, XLPD antikoerper, RGD1562408 antikoerper, Gm686 antikoerper, SH2D1A antikoerper, SH2 domain containing 1A antikoerper, SH2D1A antikoerper, Sh2d1a antikoerper
    Hintergrund

    Synonyms: SH2 domain protein 1A, DSHP, Duncan disease SH2 protein, SAP, Signaling lymphocyte activation molecule associated protein, SLAM associated protein, T cell signal transduction molecule SAP, SH21A_HUMAN.

    Background: SH2D1A, also SH2 domain protein 1A, SAP and CD150/SLAM (signaling lymphocyte activation molecule)-associated protein, influences signaling pathways involving SLAM molecules at the interface between T and B cells. SH2D1A modulates SLAM by blocking the recruitment of tyrosine phosphatase SHP2 to the phosphorylated cytoplasmic domain of SLAM. SLAM activation mediates expansion of activated T cells during immune responses, induces production of interferon-?and changes the functional profile of subsets of T cells. SH2D1A is a hydrophilic, 128 amino acid protein that is 96 % homologous to the mouse protein in both SH2 and tail domains. SH2D1A is present in all major subsets of T cells, including CD4+, CD45RO+, CD45RA+ and CD8+, but not in B cells. SH2D1A can interact via an SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of cell-surface receptors SLAM (CD150), CD84, CD229 (LY9) and CD244 (2B4).

    Gen-ID
    4068
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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