GFI1B Antikörper (Biotin)

Produktnummer ABIN1405213

Produktdetails anti-GFI1B Antikörper (Biotin)

Target: GFI1B (Growth Factor Independent 1B Transcription Repressor (GFI1B))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GFI1B Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GFI1B

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu GFI1B

Target: GFI1B (Growth Factor Independent 1B Transcription Repressor (GFI1B))

Andere Bezeichnung: GFI1B (GFI1B Produkte)

Synonyme: GFI1B antikoerper, GFI antikoerper, znf544 antikoerper, MGC80648 antikoerper, Gfi-1B antikoerper, growth factor independent 1B transcriptional repressor antikoerper, growth factor independent 1B transcription repressor L homeolog antikoerper, Zinc finger protein Gfi-1b antikoerper, growth factor independent 1B antikoerper, GFI1B antikoerper, Gfi1b antikoerper, gfi1b.L antikoerper, gfi1b antikoerper

Hintergrund:

Synonyms: Potential regulator of CDKN1A translocated in CML, GFI 1B, GFI-1B, gfi1b, GFI1B protein, GFI1B_HUMAN, Growth factor independent 1B protein, Growth factor independent protein 1B, Potential regulator of CDKN1A, Translocated in CML, Zinc finger protein Gfi-1b.

Background: Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Transcriptional repressor or activator depending on both promoter and cell type context, represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1, GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription, as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.

Gen-ID: 8328

Pathways: Cellular Response to Molecule of Bacterial Origin