VISTA Antikörper (AbBy Fluor® 350)
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- Target Alle VISTA Antikörper anzeigen
- VISTA (V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser VISTA Antikörper ist konjugiert mit AbBy Fluor® 350
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Applikation
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Human
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human SISP1/GI24
- Isotyp
- IgG
- Top Product
- Discover our top product VISTA Primärantikörper
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- Applikationshinweise
- IF(IHC-P) 1:50-200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- VISTA (V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA))
- Andere Bezeichnung
- GI24 (VISTA Produkte)
- Synonyme
- MGC112715 antikoerper, MGC151567 antikoerper, B7-H5 antikoerper, B7H5 antikoerper, GI24 antikoerper, PP2135 antikoerper, SISP1 antikoerper, Dies1 antikoerper, VISTA antikoerper, V-set immunoregulatory receptor antikoerper, vsir antikoerper, Vsir antikoerper, VSIR antikoerper
- Hintergrund
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Synonyms: C10orf54, GI24_HUMAN, Platelet receptor Gi24, PP2135, SISP1, stress induced secreted protein 1, UNQ730/PRO1412.
Background: Platelet receptor GI24, also known as SISP1 or PP2135, is a 311 amino acid single-pass type I membrane protein that contains one Ig-like (immunoglobulin-like) domain. GI24 is thought to contribute to tumor-invasive growth in the collagen matrix and is encoded by a gene that maps to human chromosome 10q22.1. Chromosome 10 contains over 800 genes, 135 million nucleotides and comprises nearly 4.5 % of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. The chromosome 10 encoded gene ERCC6 is important for DNA repair and is linked to Cockayne syndrome which is characterized by extreme photosensitivity and premature aging. Tetrahydrobiopterin deficiency and a number of syndromes involving defective skull and facial bone fusion are also linked to chromosome 10. As with most trisomies, trisomy 10 is rare and is deleterious.
- Pathways
- Cancer Immune Checkpoints
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