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GLDN Antikörper (AA 365-460) (Cy7)

GLDN Reaktivität: Human, Maus, Ratte WB, IF (p), IF (cc) Wirt: Kaninchen Polyclonal Cy7
Produktnummer ABIN1406760
  • Target Alle GLDN Antikörper anzeigen
    GLDN (Gliomedin (GLDN))
    Bindungsspezifität
    • 14
    • 7
    • 6
    • 6
    • 6
    • 3
    • 1
    AA 365-460
    Reaktivität
    • 35
    • 20
    • 20
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 34
    • 1
    Kaninchen
    Klonalität
    • 35
    Polyklonal
    Konjugat
    • 8
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GLDN Antikörper ist konjugiert mit Cy7
    Applikation
    • 35
    • 17
    • 12
    • 12
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    Kreuzreaktivität
    Human, Maus, Ratte
    Homologie
    Dog,Cow,Sheep,Pig,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Gliomedin/COLM
    Isotyp
    IgG
    Top Product
    Discover our top product GLDN Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    GLDN (Gliomedin (GLDN))
    Andere Bezeichnung
    Gliomedin (GLDN Produkte)
    Synonyme
    CLOM antikoerper, COLM antikoerper, CRG-L2 antikoerper, CRGL2 antikoerper, UNC-112 antikoerper, Clom antikoerper, Colm antikoerper, Crgl2 antikoerper, Crlg2 antikoerper, gliomedin antikoerper, GLDN antikoerper, Gldn antikoerper, gldn antikoerper
    Hintergrund

    Synonyms: CANCER RELATED GENE LIVER 2, Cancer related gene-Liver 2, CLOM, collomin, Colm gene name, COLM, Colmedin, CRG L2, FLJ23917, Gldn gene name, UNC 112, GLDN_HUMAN.

    Background: Gliomedin is a 551 amino acid protein encoded by the human gene GLDN. Gliomedin is thought to play a role in the formation of the nodes of Ranvier along myelinated axons. Accumulation of Na+ channels at the nodes of Ranvier is a prerequisite for saltatory conduction. In peripheral nerves, clustering of these channels along the axolemma is regulated by myelinating Schwann cells through an unknown mechanism. Gliomedin is a glial ligand for Neurofascin and NrCAM, two axonal immunoglobulin cell adhesion molecules that are associated with Na+ channels at the nodes of Ranvier. Gliomedin is expressed by myelinating Schwann cells and accumulates at the edges of each myelin segment during development, where it aligns with the forming nodes. Gliomedin is a single-pass type II membrane protein localized to the nodes of Ranvier and is specifically expressed in spinal cord, brain, placenta and sciatic nerve. It is more abundant in peripheral than central nervous system.

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