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Nogo B Receptor Antikörper (AA 167-210) (Cy3)

NUS1 Reaktivität: Human WB, IF (p), IF (cc) Wirt: Kaninchen Polyclonal Cy3
Produktnummer ABIN1409337
  • Target Alle Nogo B Receptor (NUS1) Antikörper anzeigen
    Nogo B Receptor (NUS1)
    Bindungsspezifität
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 167-210
    Reaktivität
    • 20
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 19
    • 1
    Kaninchen
    Klonalität
    • 19
    • 1
    Polyklonal
    Konjugat
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Nogo B Receptor Antikörper ist konjugiert mit Cy3
    Applikation
    • 20
    • 12
    • 12
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human NGBR/Nogo B receptor
    Isotyp
    IgG
    Top Product
    Discover our top product NUS1 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    Nogo B Receptor (NUS1)
    Andere Bezeichnung
    NGBR/Nogo B receptor (NUS1 Produkte)
    Synonyme
    C6orf68 antikoerper, MGC:7199 antikoerper, NgBR antikoerper, TANGO14 antikoerper, 1600027K07Rik antikoerper, AU019165 antikoerper, AW538011 antikoerper, BC003223 antikoerper, D10Ertd438e antikoerper, NUS1 dehydrodolichyl diphosphate synthase subunit antikoerper, NUS1 antikoerper, Nus1 antikoerper
    Hintergrund

    Synonyms: C6orf68, NGBR, nuclear undecaprenyl pyrophosphate synthase 1 homolog, NUS1, NGBR_HUMAN, Dehydrodolichyl diphosphate synthase complex subunit NUS1, Cis-prenyltransferase subunit NgBR, Nogo-B receptor.

    Background: Nogo is an oligodendrocyte-specific member of the Reticulon family and is a component of CNS white matter that inhibits axon outgrowth, induces collapse of growth cones of chick dorsal root ganglion cells, and inhibits the spreading of 3T3 fibroblasts. Nogo is expressed by oligodendrocytes but not by Schwann cells and associates primarily with the endoplasmic reticulum. Nogo exists in three different splice forms, Nogo-A, -B and -C. NgBR (Nogo-B receptor), also known as nuclear undecaprenyl pyrophosphate synthase 1 homolog, is a 293 amino acid single-pass type I membrane protein that acts as a specific receptor for the amino-terminus of Nogo-B. Through this interaction, NgBR is involved in the regulation of vascular remodeling and angiogenesis. NgBR also enhances Niemann-Pick type C2 protein (NPC2) stabilization. Knockdown of NgBR mRNA leads to decreased NPC2 levels, which results in the hallmarks of NPC2 mutation: increased intracellular cholesterol accumulation and a loss of sterol sensing.

    Gen-ID
    116150
    UniProt
    Q96E22
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