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RGMB Antikörper (AA 58-160) (Cy3)

RGMB Reaktivität: Human WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal Cy3
Produktnummer ABIN1409373
  • Target Alle RGMB Antikörper anzeigen
    RGMB (RGM Domain Family, Member B (RGMB))
    Bindungsspezifität
    • 14
    • 8
    • 8
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 58-160
    Reaktivität
    • 38
    • 6
    • 2
    • 1
    Human
    Wirt
    • 37
    • 1
    Kaninchen
    Klonalität
    • 38
    Polyklonal
    Konjugat
    • 15
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RGMB Antikörper ist konjugiert mit Cy3
    Applikation
    • 38
    • 14
    • 12
    • 12
    • 7
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Pig,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Repulsive Guidance Molecule B
    Isotyp
    IgG
    Top Product
    Discover our top product RGMB Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    RGMB (RGM Domain Family, Member B (RGMB))
    Andere Bezeichnung
    RGMB/Repulsive Guidance Molecule B (RGMB Produkte)
    Synonyme
    dragon antikoerper, DRAGON antikoerper, 1110059F19Rik antikoerper, repulsive guidance molecule family member b antikoerper, repulsive guidance molecule family member B antikoerper, rgmb antikoerper, RGMB antikoerper, Rgmb antikoerper
    Hintergrund

    Synonyms: Dragon, DRG11-responsive axonal guidance and outgrowth of neurite, Repulsive Guidance Molecule B, RGM b, RGM domain family member B, Rgmb, RGMB_HUMAN.

    Background: The repulsive guidance molecule (RGM) family of proteins are important in the guidance of growth cones of developing neurons. They are repulsive for a group of axons, those from the temporal half of the retina. RGM have been implicated in both axonal guidance and neural tube closure but as opposed to for ephrins, semaphorins, netrins and slits, no receptor mechanism for RGM activation has been defined. Dorsal root ganglion axons do not respond to RGM but neogenin (a netrin-binding protein which can function as an RGM receptor) expression can spur RGM responsiveness. The RGM proteins are attached to the membrane by a GPI-anchor. Two members of this family, RGMa and RGMb, are expressed in the nervous system. RGMc, also known as Hemojuvelin, is a part of the signaling pathway activating hepcidin and works together with hepcidin to restrict iron absorption in the gut. Defects in the gene encoding for RGMc causes the autosomal recessive disorder juvenile hemochromatosis (JH).

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