WWC1 Antikörper (AA 351-450) (Cy3)

Produktnummer ABIN1409943

Produktdetails anti-WWC1 Antikörper (Cy3)

Target: WWC1 (WW and C2 Domain Containing 1 (WWC1))

Bindungsspezifität: AA 351-450

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WWC1 Antikörper ist konjugiert mit Cy3

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Sheep,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KIBRA

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu WWC1

Target: WWC1 (WW and C2 Domain Containing 1 (WWC1))

Andere Bezeichnung: KIBRA (WWC1 Produkte)

Synonyme: CG12600 antikoerper, CG33967 antikoerper, CG7552 antikoerper, Dmel\\CG33967 antikoerper, Kibra antikoerper, ORE-2 antikoerper, RE26350 antikoerper, kib antikoerper, l(3)02404 antikoerper, l(3)j5C3 antikoerper, l(3)neo42 antikoerper, HBEBP3 antikoerper, HBEBP36 antikoerper, KIBRA antikoerper, AA408228 antikoerper, AU017197 antikoerper, BC037006 antikoerper, mKIAA0869 antikoerper, CG33967 gene product from transcript CG33967-RB antikoerper, WW and C2 domain containing 1 antikoerper, WW, C2 and coiled-coil domain containing 1 antikoerper, kibra antikoerper, WWC1 antikoerper, Wwc1 antikoerper

Hintergrund:

Synonyms: KIBRA, HBEBP3, HBEBP36, MEMRYQTL, PPP1R168, Protein KIBRA, HBeAg-binding protein 3, Kidney and brain protein, WW domain-containing protein 1, WWC1, KIAA0869

Background: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance.

Gen-ID: 23286

UniProt: Q8IX03