DISP2 Antikörper (AA 1101-1200) (HRP)

Produktnummer ABIN1410056

Produktdetails anti-DISP2 Antikörper (HRP)

Target: DISP2 (Dispatched Homolog 2 (DISP2))

Bindungsspezifität: AA 1101-1200

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DISP2 Antikörper ist konjugiert mit HRP

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DISP2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu DISP2

Target: DISP2 (Dispatched Homolog 2 (DISP2))

Andere Bezeichnung: DISP2 (DISP2 Produkte)

Synonyme: DISP2 antikoerper, DISPB antikoerper, HsT16908 antikoerper, AI840597 antikoerper, B230210L08Rik antikoerper, DispB antikoerper, mKIAA1742 antikoerper, dispatched RND transporter family member 2 antikoerper, dispatched RND tramsporter family member 2 antikoerper, dispatched homolog 2 (Drosophila) antikoerper, DISP2 antikoerper, Disp2 antikoerper

Hintergrund:

Synonyms: DISPB, HsT16908, Protein dispatched homolog 2, DISP2, KIAA1742

Background: DISP2 is the second of three known homologs of the D.melanogaster protein Dispatched. It is a multitransmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants. At least two isoforms of DISP2 are known to exist.

Gen-ID: 85455

UniProt: A7MBM2

Pathways: Hedgehog Signalweg