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Shootin-1 (SHTN1) (AA 21-130) Antikörper (Cy3)

SHTN1 Reaktivität: Human, Ratte WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal Cy3
Produktnummer ABIN1411659
  • Target Alle Shootin-1 (SHTN1) Antikörper anzeigen
    Shootin-1 (SHTN1)
    Bindungsspezifität
    • 14
    • 2
    • 1
    • 1
    AA 21-130
    Reaktivität
    • 24
    • 17
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Ratte
    Wirt
    • 24
    Kaninchen
    Klonalität
    • 24
    Polyklonal
    Konjugat
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cy3
    Applikation
    • 18
    • 12
    • 12
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human, Ratte
    Homologie
    Mouse,Cow,Pig,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Shootin/KIAA1598
    Isotyp
    IgG
    Top Product
    Discover our top product SHTN1 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    Shootin-1 (SHTN1)
    Andere Bezeichnung
    Shootin/KIAA1598 (SHTN1 Produkte)
    Synonyme
    Kiaa1598 antikoerper, Shootin1 antikoerper, mKIAA1598 antikoerper, shootin 1 antikoerper, SHTN1 antikoerper, Shtn1 antikoerper
    Hintergrund

    Synonyms: DKFZp686A0439, hypothetical protein FLJ11122, Kiaa1598, MGC40476, Putative uncharacterized protein KIAA1598, Shootin 1, Shootin-1, SHOT1_HUMAN.

    Background: Shootin1 is a 631 amino acid protein that belongs to the shootin family. The shootin1 protein contains three coiled-coil domains, a proline-rich region and interacts with RUFY3. Shootin1 is involved in the generation of internal asymmetric signals required for neuronal polarization. The shootin1 protein acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K activity. By accumulating asymmetrically in a single neurite before polarization, shootin1 leads to axon induction for polarization, additionally the absence of shootin1 from the nascent axon's siblings by competition prevents the formation of surplus axons. Existing as seven alternatively spliced isoforms, the shootin1 gene is conserved in chimpanzee, dog, mouse, rat, chicken and zebrafish, and maps to human chromosome 10q25.3.

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